gms | German Medical Science

72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

06.06. - 09.06.2021

Threedimensional reconstruction of individual brain anatomy in patients with glioblastoma

Dreidimensionale Rekonstruktion der individuellen Gehirnanatomie bei Patienten mit Glioblastom

Meeting Abstract

  • presenting/speaker Katharina Hense - Universitätsklinikum Regensburg, Röntgendiagnostik, Regensburg, Deutschland
  • Katharina Rosengarth - Universitätsklinikum Regensburg, Klinik und Poliklinik für Neurochirurgie, Regensburg, Deutschland
  • Christina Wendl - Universitätsklinikum Regensburg, Röntgendiagnostik, Regensburg, Deutschland
  • Nils Ole Schmidt - Universitätsklinikum Regensburg, Klinik und Poliklinik für Neurochirurgie, Regensburg, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie. sine loco [digital], 06.-09.06.2021. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocP126

doi: 10.3205/21dgnc414, urn:nbn:de:0183-21dgnc4141

Published: June 4, 2021

© 2021 Hense et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.


Outline

Text

Objective: Considering the current literature on the examination of functional magnetic resonance imaging of brain tumors, it is noticeable that Statistical Parametric Mapping 12 (SPM12) dominates as an evaluation tool. Overall, there are only few studies using the FreeSurfer software to analyze data from patients with cranial tumors, as this often leads to flawed reconstructions of the brain anatomy. In this study, we want to present and evaluate a pre-processing approach that supports such reconstruction with a minimum of subjective influence on the data.

Methods: Here, we analyzed structural MRI data from 30 patients with a glioblastoma as these patients showed most flawed cortical reconstructions in previous attempts due to huge areas of edema and contrast enhancement. The tumor is first segmented using an automated software and replaced by healthy tissue of the contralateral hemisphere using enantiomorphic normalization. The resulting processed anatomical image was the basis for the three-dimensional anatomical reconstruction in FreeSurfer. These reconstructions were subsequently used to perform a first level functional analysis which was compared to the results obtained with SPM12.

Results: After establishing the pre-processing protocol presented, these patient brains showed significantly fewer errors when performing the described steps before running the reconstruction compared to the application of standard FreeSurfer protocols. More than 90% of cases were even reconstructed without errors. Comparisons with functional results obtained using the SPM12 showed similar activation patterns in both methods.

Conclusion: The pre-processing protocol established here allows the three-dimensional reconstruction of the individual brain anatomy of patients with brain tumors which radiologically even show the most inhomogeneous form of brain tumor. Therefore, it can be used as a basis for further analyses of patients data and it might even be possible to integrate this protocol in clinical setups of presurgical functional imaging.