Article
Infiltration of vestibular schwannomas with inflammatory cells is associated with increased tumour size but not with volumetric growth
Infiltration von Vestibularisschwannomen mit inflammatorischen Zellen ist mit einem größeren Tumorvolumen aber nicht mit einem volumetrischen Wachstum assoziiert
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Published: | June 4, 2021 |
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Objective: The impact of inflammatory processes in vestibular schwannoma growth has been suggested by prior studies. A clear impact of inflammatory cell infiltration and tumor size growth has not yet been shown in a detailed volumetric analysis.
Methods: We performed immunohistochemical analyses of inflammatory cell markers (CD3, CD8, CD68 and CD163) in 923 newly diagnosed sporadic vestibular schwannomas. We constructed an inflammatory score based on the immunohistochemical marker scores of each tumor. Volumetric measurement of preopertaive images was done. The immunohistochemical results were compared with preoperative radiographic tumor volume and volumetric growth.
Results: A higher tumor volume prior to resection was seen in vestibular schwannomas with an increased infiltration with CD3, CD8, CD68, CD163 positive cells. There was no difference in volumetric tumor growth when regarded for each marker separately. But when the immunohistochemical results were taken together as an inflammatory score, a slower growth rate with higher inflammatory score was observed.
Conclusion: Infiltration of vestibular schwannomas with inflammatory cells is associated with increased tumor volume but slower growth.