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72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

06.06. - 09.06.2021

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Untreated cerebral cavernous malformations (CCM) – quality of life in one-year longitudinal follow up

Cerebrale Kavernome – Entwicklung der Lebensqualität im longitudinalen Ein-Jahresverlauf

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  • presenting/speaker Annika Herten - Universitätsklinikum Essen, Klinik für Neurochirurgie, Essen, Deutschland
  • Dino-Vitali Saban - Universitätsklinikum Essen, Klinik für Neurochirurgie, Essen, Deutschland
  • Bixia Chen - Universitätsklinikum Essen, Klinik für Neurochirurgie, Essen, Deutschland
  • Laurèl Rauschenbach - Universitätsklinikum Essen, Klinik für Neurochirurgie, Essen, Deutschland
  • Alejandro Nicolas Santos - Universitätsklinikum Essen, Klinik für Neurochirurgie, Essen, Deutschland
  • Steffen Rauscher - Universitätsklinikum Essen, Klinik für Neurochirurgie, Essen, Deutschland
  • Ramazan Jabbarli - Universitätsklinikum Essen, Klinik für Neurochirurgie, Essen, Deutschland
  • Karsten Henning Wrede - Universitätsklinikum Essen, Klinik für Neurochirurgie, Essen, Deutschland
  • Ulrich Sure - Universitätsklinikum Essen, Klinik für Neurochirurgie, Essen, Deutschland
  • Philipp Dammann - Universitätsklinikum Essen, Klinik für Neurochirurgie, Essen, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie. sine loco [digital], 06.-09.06.2021. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocV301

doi: 10.3205/21dgnc285, urn:nbn:de:0183-21dgnc2851

Published: June 4, 2021

© 2021 Herten et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Objective: To estimate quality of life (QoL) during the natural course of patients with untreated cerebral cavernous malformations (CCM) using a one-year longitudinal follow up.

Methods: 246 consecutive cases of CCM were included in a prospective longitudinal study assessing QoL and neurological/psychiatric constitution over the past two years in our institution. QoL was assessed by SF 36 survey (2 sum scores (physical sum score PCS/mental sum score MCS) and 8 subdomains (physical function PF, role bodily BR, bodily pain BP, general health GH, vitality VIT, social functioning SF, role emotional ER, mental health MH)), psychiatric constitution by HADS-A/D and functional condition by modified Rankin score. Longitudinal follow-up was achieved within 12 months ± 2 months. Pairwise comparison of data was performed by Wilcoxon test.

Results: So far, 73 patients of the whole cohort were re-assessed at the one year follow up, 4 were excluded as they underwent surgical treatment of the CCM in between the surveys. Therefore, n= 69 cases were included in a preliminary analysis. In these, CCM were located supratentorial (71%), in the brainstem (26%) and cerebellar (3%). Five patients showed multiple CCM, 10 suffered from cavernoma related epilepsy (CRE) and 33 were asymptomatic. Twenty-eight patients (40%) had an initial symptomatic hemorrhage. Two patients suffered from a bleeding event in between the 2 surveys. Comparing longitudinal QoL values, no significant improvement or deterioration was found. Longitudinal HADS-A scores improved significantly (p= 0.047). Subgroup analysis revealed that patients with CRE showed deterioration in most QOL subdomains and component scores.

Conclusion: It is known that diagnosis of CCM effects QoL and mental state (anxiety and depression). Our data reveals that at untreated one-year follow up, QOL does not significantly change, but anxiety levels improve (HADS-A). The latter may reflect an improvement in coping with the diagnosis. Suffering from CRE leads to decrease of QOL reflecting the specific burden of epilepsy.