gms | German Medical Science

72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

06.06. - 09.06.2021

Quality of life after treatment of patients with tumours of peripheral nerves – results from the retrospective study arm of a multicentre registry

Lebensqualität nach der Behandlung peripherer Nerventumoren – Ergebnisse des retrospektiven Studienarms eines multizentrischen Registers

Meeting Abstract

  • presenting/speaker Nadja Grübel - Universitätsklinik Ulm am Bezirkskrankenhaus Günzburg, Neurochirurgie, Günzburg, Deutschland
  • Gregor Antoniadis - Universitätsklinik Ulm am Bezirkskrankenhaus Günzburg, Neurochirurgie, Günzburg, Deutschland
  • Ralph König - Universitätsklinik Ulm am Bezirkskrankenhaus Günzburg, Neurochirurgie, Günzburg, Deutschland
  • Christian Rainer Wirtz - Universitätsklinik Ulm am Bezirkskrankenhaus Günzburg, Neurochirurgie, Günzburg, Deutschland
  • Christina Otte - Charité Universitätsmedizin, Klinik für Neurochirurgie, Berlin, Deutschland
  • Peter Vajkoczy - Charité Universitätsmedizin, Klinik für Neurochirurgie, Berlin, Deutschland
  • Nora Dengler - Charité Universitätsmedizin, Klinik für Neurochirurgie, Berlin, Deutschland
  • Maria Pedro - Universitätsklinik Ulm am Bezirkskrankenhaus Günzburg, Neurochirurgie, Günzburg, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie. sine loco [digital], 06.-09.06.2021. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocV202

doi: 10.3205/21dgnc197, urn:nbn:de:0183-21dgnc1972

Published: June 4, 2021

© 2021 Grübel et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.


Outline

Text

Objective: Peripheral nerve tumors are rare diseases. So far, no multicenter data on long-term outcomes, efficacy of treatment and diagnostics or on life quality exists. The establishment of the peripheral nerve tumor registry (PNTR) in 2017 allows for systematic analysis of patients with tumor in association to peripheral nerves. To what extent life quality might be affected by the disease has never been studied.

Methods: Quality of life was assessed by the Euro-Qol-5D-5L (EQ-5D-5L) and Euro-Qol visual analog scale (EQ-VAS) survey at follow-up in the retrospective study arm in 2 out of 8 participating study centers. An index is calculated based upon EQ-5D-5L for quantification of health state (<0: worst possible state of health, 1: best possible state of health). The EQ VAS ranges from 0 (worst possible health status) to 100 (best possible health status). Patient characteristics (age, sex) as well as disease (histopahology) and treatment (pre- and postoperative symptoms, type of treatment) specific data was analyzed.

Results: EQ-5D-5L survey were sent to 96 patients. Response rate was 35 % (n=36, mean age of 44 years, 14 female, 22 male patients). Most frequent histopathology w schwannoma(n=24) and perineurioma (n=5). Other histopathologies were neurofibroma (n=2), malignant peripheral nerve sheath tumor (MPNST) (n=2), non-hodgkin lymphoma (n=1), plexiform neurofibroma (n=1) and fibromyosarcoma (n=1). Prevailing preoperative symptoms were pain in 44 %, motor deficits in 28 %, and sensory deficits in 50 %. Patients were treated by complete tumor resection (89 %) or biopsy (11 %). Reported symptoms in the actual survey were pain in 17 %, motor deficits in 36 % and sensory deficits in 56 %. Quality of life was assessed at a mean of 48 months after initial presentation and treatment. Only 22% of patients reached the highest index score of 1.0 in EQ-5D-5L. Patients with MPNSTs and perineurinoma reported severe problems in the dimension anxiety and pain (Table 1 [Tab. 1]). In the Euro-Qol Visual Analog Scale (VAS) patients rated their overall health with a median of 80 (25-100).

Conclusion: Measures of life quality in patient with peripheral nerve tumors reported higher numbers of problems in the 5 dimensions of EQ-5D-5L compared to the General population in Germany. Type of tumor might be the most significant factor affecting life quality in the dimension of pain and anxiety.