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72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

06.06. - 09.06.2021

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Is there an impact of total nimodipine dosage on postoperative hearing preservation/cranial nerve function after vestibular schwannoma resection? A retrospective analysis of a randomised, multicentre trial

Gibt es einen Zusammenhang zwischen der Gesamtmenge an verabreichtem Nimodipin und dem Erhalt der Funktionen der Hör- und Fazialisnerven nach der Resektion von Vestibularis-Schwannomen? Eine retrospektive Analyse einer randomisierten und multizentrischen Studie

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  • presenting/speaker Christian Scheller - University of Halle-Wittenberg, Neurosurgery, Halle/Saale, Deutschland
  • Pia Haenel - University of Halle-Wittenberg, Neurosurgery, Halle/Saale, Deutschland
  • Stefan Rampp - University of Halle-Wittenberg, Neurosurgery, Halle/Saale, Deutschland
  • Sandra Leisz - University of Halle-Wittenberg, Neurosurgery, Halle/Saale, Deutschland
  • Marcos Tatagiba - University of Tübingen, Department of Neurosurgery and Neurotechnology, Tübingen, Deutschland
  • Alireza Gharabaghi - University of Tübingen, Department of Neurosurgery and Neurotechnology, Tübingen, Deutschland
  • Kristofer Ramina - University of Tübingen, Department of Neurosurgery and Neurotechnology, Tübingen, Deutschland
  • Oliver Ganslandt - Klinikum Stuttgart, Katharinenhospital, Neurosurgery, Stuttgart, Deutschland
  • Cordula Matthies - University of Würzburg, Neurosurgery, Würzburg, Deutschland
  • Thomas Westermaier - University of Würzburg, Neurosurgery, Würzburg, Deutschland; Helios Amper Klinikum, Neurochirurgie, Dachau, Deutschland
  • Maria Pedro - University of Ulm, Neurosurgery, Günzburg, Deutschland
  • Veit Rohde - University of Göttingen, Neurosurgery, Göttingen, Deutschland
  • Kajetan Ludolf von Eckardstein - University of Göttingen, Neurosurgery, Göttingen, Deutschland; Westpfalz-Klinikum Kaiserslautern, Neurosurgery, Kaiserslautern, Deutschland
  • Christian Strauss - University of Halle-Wittenberg, Neurosurgery, Halle/Saale, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie. sine loco [digital], 06.-09.06.2021. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocV122

doi: 10.3205/21dgnc117, urn:nbn:de:0183-21dgnc1176

Published: June 4, 2021

© 2021 Scheller et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Objective: This study aims to evaluate the relationship of total nimodipine dosage, tumor size, hearing and facial nerve preservation in vestibular schwannoma surgery.

Methods: In a retrospective analysis the data of 93 patients out of 112 patients of a randomized, multicenter trial that investigated the efficacy of prophylactic nimodipine treatment in vestibular schwannoma surgery were examined. Logistic regression analysis was applied in order to observe the correlation between total nimodipine dosage and postoperative hearing preservation and facial nerve function with respect to tumor size.

Results: Logistic regression analysis showed significant correlation of total nimodipine dosage and postoperative hearing preservation (p=0.049), tumor size (p=0.023) as well as their interaction with postoperative hearing preservation (p=0.043). Comparable analysis of postoperative function of the facial nerve did not correlate significantly with the total nimodipine dosage.

Conclusion: It can be proposed that a higher total nimodipine dosage and a lower tumor size describe better chances for postoperative hearing preservation. Moreover, the positive effect on the preservation of hearing due to higher total nimodipine dosage can especially be seen/ is especially relevant in patients with bigger tumor sizes.