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72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

06.06. - 09.06.2021

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Aneurysm wall enhancement is associated with decreased intrasaccular IL-10 and morphological features of instability

Assoziation von Kontrastmittelanreicherung in der Wand von intrakraniellen Aneurysmen mit einer verminderten intraaneurysmatischen Konzentration von IL-10 und morphologischen Instabilitätsparametern

Meeting Abstract

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  • Vanessa M. Swiatek - Otto-von-Guericke University Magdeburg, Department of Neurosurgery, Magdeburg, Deutschland
  • presenting/speaker Belal Neyazi - Otto-von-Guericke University Magdeburg, Department of Neurosurgery, Magdeburg, Deutschland
  • Jorge A. Roa - University of Iowa Hospitals and Clinics, Department of Neurosurgery, Iwoa City, IA, Vereinigte Staaten; University of Iowa Hospitals and Clinics, Department of Neurology, Iwoa City, IA, Vereinigte Staaten
  • Mario Zanaty - University of Iowa Hospitals and Clinics, Department of Neurosurgery, Iwoa City, IA, Vereinigte Staaten
  • Edgar A. Samaniego - University of Iowa Hospitals and Clinics, Department of Neurosurgery, Iwoa City, IA, Vereinigte Staaten; University of Iowa Hospitals and Clinics, Department of Neurology, Iwoa City, IA, Vereinigte Staaten
  • Daizo Ishii - University of Iowa Hospitals and Clinics, Department of Neurosurgery, Iwoa City, IA, Vereinigte Staaten
  • Yongjun Lu - University of Iowa Hospitals and Clinics, Department of Neurosurgery, Iwoa City, IA, Vereinigte Staaten
  • I. Erol Sandalcioglu - Otto-von-Guericke University Magdeburg, Department of Neurosurgery, Magdeburg, Deutschland
  • Sylvia Saalfeld - Otto-von-Guericke University Magdeburg, Department of Simulation and Graphics, Magdeburg, Deutschland; Research Campus STIMULATE, Magdeburg, Deutschland
  • Philipp Berg - Research Campus STIMULATE, Magdeburg, Deutschland; Otto-von-Guericke University Magdeburg, Department of Fluid Dynamics and Technical Flows, Magdeburg, Deutschland
  • David Hasan - University of Iowa Hospitals and Clinics, Department of Neurosurgery, Iwoa City, IA, Vereinigte Staaten

Deutsche Gesellschaft für Neurochirurgie. 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie. sine loco [digital], 06.-09.06.2021. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocV036

doi: 10.3205/21dgnc038, urn:nbn:de:0183-21dgnc0384

Published: June 4, 2021

© 2021 Swiatek et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

Text

Objective: High resolution vessel wall imaging plays an increasingly important role in assessing the risk of aneurysm rupture. We aim to introduce an approach towards the validation of the wall enhancement as a direct surrogate parameter for aneurysm stability.

Methods: 19 patients harboring 22 incidental, intracranial aneurysms were enrolled in this study. The aneurysms were dichotomized according to their aneurysm-to–pituitary stalk contrast ratio using a cut-off value of 0.5 (stable <0.5; unstable ≥0.5). We evaluated the association of aneurysm wall enhancement with morphological characteristics, hemodynamic features and inflammatory chemokines directly measured inside the aneurysm.

Results: Differences in plasma concentration of chemokines and inflammatory molecules, morphological and hemodynamic parameters were analyzed using the Welch test or Mann-Whitney-U test. The concentration Δinterleukin-10 in the lumen of intracranial aneurysms with low wall enhancement was significantly increased compared to aneurysms with strong aneurysm wall enhancement (p = 0.014). The analysis of morphological and hemodynamic parameters showed significantly increased values for Aneurysm Volume (p = 0.03), Aneurysm Area (p = 0.044), maximal diameter (p = 0.049) and non-sphericity index (p = 0.021) for intracranial aneurysms with strong aneurysm wall enhancement. None of the hemodynamic parameters reached statistical significance, however, the total viscous shear force computed over the region of low wall shear stress showed a strong tendency towards significance (p = 0.053).

Conclusion: Aneurysmal wall enhancement shows strong associations with decreased intrasaccular IL-10 and established morphological indicators of aneurysm instability.