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72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

06.06. - 09.06.2021

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Quality of life in adult Moyamoya patients – preoperative assessment and correlation to MRI and H215O-PET findings

Beeinträchtigung der Lebensqualität bei erwachsenen Patienten mit Moyamoya – präoperative Beurteilung und Korrelation mit MRT und H215O-PET

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  • presenting/speaker Patrick Haas - Universitätsklinikum Tübingen, Klinik für Neurochirurgie, Tübingen, Deutschland; Universitätsklinikum Tübingen, Zentrum für Moyamoya und cerebrale Revaskularisation, Tübingen, Deutschland
  • Monika Fudali - Universitätsklinikum Tübingen, Klinik für Neurochirurgie, Tübingen, Deutschland; Universitätsklinikum Tübingen, Zentrum für Moyamoya und cerebrale Revaskularisation, Tübingen, Deutschland
  • Helene Hurth - Universitätsklinikum Tübingen, Klinik für Neurochirurgie, Tübingen, Deutschland; Universitätsklinikum Tübingen, Zentrum für Moyamoya und cerebrale Revaskularisation, Tübingen, Deutschland
  • Sophie Wang - Universitätsklinikum Tübingen, Klinik für Neurochirurgie, Tübingen, Deutschland; Universitätsklinikum Tübingen, Zentrum für Moyamoya und cerebrale Revaskularisation, Tübingen, Deutschland
  • Marcos Tatagiba - Universitätsklinikum Tübingen, Klinik für Neurochirurgie, Tübingen, Deutschland
  • Nadia Khan - Universitätskinderspital Zürich, Moyamoya Center, Zürich, Schweiz
  • Constantin Roder - Universitätsklinikum Tübingen, Klinik für Neurochirurgie, Tübingen, Deutschland; Universitätsklinikum Tübingen, Zentrum für Moyamoya und cerebrale Revaskularisation, Tübingen, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie. sine loco [digital], 06.-09.06.2021. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocV022

doi: 10.3205/21dgnc026, urn:nbn:de:0183-21dgnc0264

Published: June 4, 2021

© 2021 Haas et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Objective: The diagnosis of Moyamoya Angiopathy (MMA) is a life-changing condition for patients. Disease-related cerebral perfusion deficits or infarctions might influence the quality of life (QoL). This study examines preoperative QoL in adult patients with MMA and correlates these results with imaging findings.

Methods: Preoperative QoL data (SF-36, SCL-90, BDI, BVI) of 67 adult moyamoya patients was analyzed for a possible correlation with territorial hypoperfusion seen on H215O PET with acetazolamide (ACZ) challenge (cerebrovascular reserve) and infarction patterns observed in MRI (FLAIR). Each vascular territory was analyzed separately and correlated to QoL.

Results: Physical role function was restricted in 41.0% of cases and emotional role function in 34.4% of cases. Compulsivity (39.3%), psychoticism (34.4%) and depression (29.5%) were also very common. Psychoticism was significantly more frequent in cases of perfusion deficits as seen in PET CT in both MCA territories (left p=0.0124, right p=0.0145) and infarctions as seen in MRI in the right MCA territory (p=0.0232). Depression was significantly associated with infarctions in the right MCA territory (p=0.0174), physical role function impairment with perfusion deficits in both MCA territories (left p=0.0178, right p=0.0428). Women were significantly more frequently affected by depression (p=0.0234).

Conclusion: This analysis shows significant impairment of QoL in preoperative testing of Moyamoya patients. The results show a correlation between individual QoL parameters and affected brain areas. Especially the right MCA territory might play a key-role for neuropsychological disorders in Moyamoya patients as also shown in previous analysis. Additional postoperative testing of Moyamoya patients is needed in the future to control the development of QoL parameters after revascularization and to possibly support patients with neuropsychological treatment.