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72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

06.06. - 09.06.2021

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Frailty detected with the Geriatric 8 health status screening tool (G8) and Groningen Frailty Index (GFI) are associated with increased post-operative morbidity and shortened overall survival in geriatric patients with glioblastoma

Assoziation der prä-operativ erfassten Gebrechlichkeit mit einer erhöhten post-operativen Morbidität und kürzeren Überlebenszeit bei geriatrischen Glioblastom-Patienten

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  • presenting/speaker Dragan Jankovic - Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Neurochirurgische Klinik und Poliklinik, Mainz, Deutschland
  • Harald Krenzlin - Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Neurochirurgische Klinik und Poliklinik, Mainz, Deutschland
  • Christoph Alberter - Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Neurochirurgische Klinik und Poliklinik, Mainz, Deutschland
  • Florian Ringel - Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Neurochirurgische Klinik und Poliklinik, Mainz, Deutschland
  • Naureen Keric - Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Neurochirurgische Klinik und Poliklinik, Mainz, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie. sine loco [digital], 06.-09.06.2021. Düsseldorf: German Medical Science GMS Publishing House; 2021. DocV003

doi: 10.3205/21dgnc003, urn:nbn:de:0183-21dgnc0032

Published: June 4, 2021

© 2021 Jankovic et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Objective: Glioblastoma is the most common primary malignant brain tumor in adults with dismal prognosis. Treatment of glioblastoma in elderly patients is particular challenging due to their general condition and comorbidities. In this study we aim to evaluate the impact of age and frailty on the surgical outcome and long-term survival in geriatric patients with glioblastoma.

Methods: Data acquisition was conducted as a single-center retrospective analysis. From 2015 to 2017 patients over 70 years of age presenting to our department with glioblastoma were included in our study. Demographic data, tumor size, Karnofsky Performance Index (KPI) and Eastern Cooperative Oncology Group Performance status (ECOG), as well as treatment modalities were documented. The Geriatric 8 health status screening tool (G8) and Groningen Frailty Index (GFI) were compiled pre- and postoperatively.

Results: 50 consecutive patients were included in our study. The mean patient age was 76.86±4.11 years and 28 (56%) patients were female. 35 patients underwent microsurgical tumor resection, 15 patients tumor biopsy, only. Frailty on admission was 5.0+-2.5 (GFI) and 12.4+-2.0 (G8), respectively. In our cohort, frailty was independent of patient age, tumor size or localization. Surgical decision making between biopsy or tumor resection was not based on preoperative frailty and did not correlate with it. Both, GFI and G8 were significant predictors of post-operative morbidity (GFI: r2=0.31, p

Conclusion: In this study, frailty proved to be a more accurate predictor for a poorer surgical outcome, the occurrence of postoperative complications and an impaired overall survival compared to age. Frailty screening tests offer an additional assessment tool to stratify geriatric patients with glioblastoma and identify those at risk for a detrimental outcome and should be considered for surgical decision making.