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71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

21.06. - 24.06.2020

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The impact of AB0 blood group on thromboembolic and haemorrhagic complications after resection of intracranial meningeomas

Einfluss der AB0 Blutgruppe auf thromboembolische Komplikationen und postoperative Nachblutungen nach Resektion inrakranieller Meningeome

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  • presenting/speaker Christopher Beynon - Universitätsklinikum Heidelberg, Neurochirurgische Klinik, Heidelberg, Deutschland
  • Vera Rösner - Universitätsklinikum Heidelberg, Neurochirurgische Klinik, Heidelberg, Deutschland
  • Leo Albrecht - Institut für Klinische Transfusionsmedizin und Zelltherapie Heidelberg gemeinnützige GmbH und Institut für Immunologie, Heidelberg, Deutschland
  • Ulrike Müller - Institut für Klinische Transfusionsmedizin und Zelltherapie Heidelberg gemeinnützige GmbH und Institut für Immunologie, Heidelberg, Deutschland
  • Klaus Zweckberger - Universitätsklinikum Heidelberg, Neurochirurgische Klinik, Heidelberg, Deutschland
  • Andreas W. Unterberg - Universitätsklinikum Heidelberg, Neurochirurgische Klinik, Heidelberg, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. sine loco [digital], 21.-24.06.2020. Düsseldorf: German Medical Science GMS Publishing House; 2020. DocP173

doi: 10.3205/20dgnc456, urn:nbn:de:0183-20dgnc4560

Published: June 26, 2020

© 2020 Beynon et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Objective: Recent studies have suggested an impact of the AB0 blood group on thromboembolic and haemorrhagic events following trauma or surgical procedures. However, only limited data are available on the impact of the AB0 blood group in neurosurgical patients. The goal of the present study was to evaluate the role of the AB0 blood group on the rate of thromboembolic and haemorrhagic events in patients treated surgically at our institution for intracranial meningeoma.

Methods: We retrospectively analysed the medical records of consecutive patients undergoing resection of intracranial meningeomas at our institution during a period of 12.5 years (2006-2018). Clinical characteristics, modalities of surgical treatment, histopathological results and the postoperative course of patients were analysed with specific focus on AB0 blood group typing result, need for transfusion of blood products, events of postoperative thromboembolism and intracranial re-haemorrhage requiring surgical revision, as well as in-hospital mortality.

Results: A total of 1781 patients were included in this study. Corresponding to their AB0 blood type, patients were subdivided into four categories: Blood group A (n=774; 43%); blood group B (n=220; 12%); blood group AB (n=87; 5%); and blood group 0 (n=700; 39%). Thromboembolic events such as pulmonary embolism occurred in a total of 29 patients (1.6%) and univariate analysis revealed no significant differences between AB0 blood groups (A: 1.6%; B: 1.4%; AB: 0%; 0: 2.0%). Intracranial re-haemorrhage requiring re-craniotomy and haematoma evacuation occurred in a total of 48 patients (2.3%) and no significant differences were observed between the AB0 blood groups (A: 2.5%; B: 2.3%; AB: 2.2%; 0: 3.1%). The overall in-hospital mortality rate was 0.17% (n=3).

Conclusion: Patients with blood group 0 had higher rates of thromboembolism and postoperative haemorrhage than other blood groups, but these differences failed to reach statistical significance. These findings suggest a limited impact of the AB0 blood group on postoperative complications after resection of intracranial meningeomas.