Article
The SHORT score for preoperative assessment of the risk for short-term survival in glioblastoma
Präoperative Einschätzung des Risikos von Kurzzeitüberleben bei Glioblastom-Patienten – der SHORT score
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Published: | June 26, 2020 |
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Outline
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Objective: Despite recent improvements in treatment of glioblastoma (GBM), some patients still show a short survival. In this study, we sought to develop a new risk score for preoperative assessment of short-term survival (STS, < 6 months) in GBM patients.
Methods: All adult patients, who underwent surgical resection of GBM between 2004 and 2014 were included (n=379). Various demographic and clinical parameters, which are available at admission, were assessed. Variables were evaluated in univariate and multivariate analyses. The score was validated in a separate GBM cohort selected for biopsy (n=170).
Results: The following independent predictors of STS were integrated into a new score: body height (Small, <169 cm, 1point), arterial Hypertension (1point), patients’ age (Older: ≤54 years – 0points, 55-74 years – 1point, ≥75 years – 2points), and poor clinical status (Reduced Karnofsky performance status scale: ≤60% – 2points, 70-80% – 1point, ≥90% – 0points). Therefore, the new risk score (SHORT [Term]) ranged from 0 to 6 points and showed a good accuracy of risk estimation for STS in GBM (AUC: 0.715). STS rates were 9.7%, 23.1% and 70% in GBM patients scoring <2 points, 2-4 points and >4 points respectively (P<0.0001). The score was successfully validated (AUC: 0.792).
Conclusion: This study suggests a new risk score for preoperative assessment of STS risk in GBM patients. Still, this risk score needs external validation in larger patients’ cohorts. Our score might be a tool to facilitate treatment decisions in GBM patients prior to surgery.