Article
Confocal laser endomicroscopy – a histological work-up of rare tumours
Konfokale Laserendomikroskopie – eine histologische Gegenüberstellung seltener Tumore
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Authors
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David Breuskin
- Universitätsklinikum des Saarlandes, Klinik für Neurochirurgie, Homburg, Deutschland
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Joachim Oertel
- Universitätsklinikum des Saarlandes, Klinik für Neurochirurgie, Homburg, Deutschland
| Published: | June 26, 2020 |
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Outline
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Objective: Confocal laserendomicroscopy (CLE) is a novel investigational technique in neurosurgery. Since the clarification of tumour histology during surgery can be crucial, neurosurgeons need to rely on frozen sections in order to gain a first evaluation. Confocal laserendomicroscopy allows neurosurgeons to evaluate tissue on a microscopic level and gain first estimates of what tumour entity is present. While we have already presented data on more common tumour entities, we aim at providing information on tumours that are rarer and could pose more difficulties for evaluation.
Methods: We have investigated 306 cases of CNS tumours with CLE. Of these, we present cases of the rarer tumor types, namely paraganglioma (n=1), pituitary adenoma (n=7), AVM (n=2), cavernoma (n=4), lymphoma (n=4), plexuspapilloma (n=1), gliosarcoma (n=1) and neuroblastoma (n=1) together with the histological work up in order to make this technology more comprehensible as well as more approachable.
Results: We were able to compare confocal laserendomicroscopic data with histological HE stained specimen in order to evaluate the images. Our work up highlights the specific characteristics of these different tumour typess and draws parallels in order to make the correct diagnostic choice.
Conclusion: Confocal laserendomicroscopy can help neurosurgeons to acquire first information on tumour entities before frozen sections are available. As soon as some knowledge and experience are acquired, CLE may become a strong complementary tool for neurooncological surgery.
