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71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

21.06. - 24.06.2020

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The STAMPE2 score is suitable to estimate postoperative seizures in meningioma patients in an independent cohort

Der STAMPE2-Score eignet sich zur Abschätzung des postoperativen Epilepsie-Risikos bei Meningeompatienten in einer unabhängigen Kohorte

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  • presenting/speaker Peter Baumgarten - Universitätsklinikum Frankfurt am Main, Klinik und Poliklinik für Neurochirurgie, Frankfurt am Main, Deutschland
  • Mana Sarlak - Universitätsklinikum Frankfurt am Main, Klinik und Poliklinik für Neurochirurgie, Frankfurt am Main, Deutschland
  • Andrea Spyrantis - Universitätsklinikum Frankfurt am Main, Klinik und Poliklinik für Neurochirurgie, Frankfurt am Main, Deutschland
  • Florian Geßler - Universitätsklinikum Frankfurt am Main, Klinik und Poliklinik für Neurochirurgie, Frankfurt am Main, Deutschland
  • Marlies Wagner - Universitätsklinikum Frankfurt am Main, Neuroradiologie, Frankfurt am Main, Deutschland
  • Patrick N. Harter - Johann Wolfgang Goethe-Universität Frankfurt am Main, Edinger Institut, Neuropathologie, Frankfurt am Main, Deutschland
  • Volker Seifert - Universitätsklinikum Frankfurt am Main, Klinik und Poliklinik für Neurochirurgie, Frankfurt am Main, Deutschland
  • Thomas Freiman - Universitätsklinikum Frankfurt am Main, Klinik und Poliklinik für Neurochirurgie, Frankfurt am Main, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. sine loco [digital], 21.-24.06.2020. Düsseldorf: German Medical Science GMS Publishing House; 2020. DocP134

doi: 10.3205/20dgnc419, urn:nbn:de:0183-20dgnc4199

Published: June 26, 2020

© 2020 Baumgarten et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Objective: Seizures are one of the most common symptoms of Meningioma patients. However, it still remains unclear whether prophylactic preoperative anticonvulsive treatment reasonable. The STAMPE2 score has been implemented by Wirsching et al. to estimate the postoperative seizure-risk. We aimed to evaluate this score in our independent cohort.

Methods: In total 556 patients (female 375 / male 181) were included. WHO grade at primary resection in 331 patients was grade I, in 197 patients grade II and in 9 patients grade III. Recurrences were also included as well. Modified STAMPE2 score was applied to our cohort and points were added as follows: Sensorimotor deficit (1pt), tumor progression (1pt), age < 55 years (1pt), major surgical complication (2pts), preoperative epilepsy (2pts) and edema (1pt).

Results: In our cohort, 58 patients showed tumor recurrence after a mean of 36 months (range 3 – 277 months) and 82 of all patients developed postoperative seizures. Setting a cut off at 4 points there was the significant difference in the occurrence of postoperative seizures between the two groups (p<0.0001, seizure risk 23% vs 49%). The seizure free survival and thus the occurrence of either early or late seizures did not correlate with the STAMPE2 score.

Conclusion: Investigating the STAMPE2 score on an independent cohort underlines that it is well suitable to estimate the seizure risk of meningioma patients and should be taken to design further studies for prophylactic anticonvulsive treatment in meningioma patients.