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71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

21.06. - 24.06.2020

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Surgery for temporal low grade-glioma – Does extent of resection impair neurocognitive outcome?

Untersuchungen zur Neurokognition bei der Chirurgie temporaler niedriggradiger Gliome in Abhängigkeit vom Resektionsausmaß

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  • presenting/speaker Inja Ilic - Rheinische Friedrich-Wilhelms-Universität Bonn, Abteilung für Neurochirurgie, Bonn, Deutschland
  • Matthias Schneider - Rheinische Friedrich-Wilhelms-Universität Bonn, Abteilung für Neurochirurgie, Bonn, Deutschland
  • Julia Taube - Rheinische Friedrich-Wilhelms-Universität Bonn, Abteilung für Epileptologie, Bonn, Deutschland
  • Gülsah Aydin - Rheinische Friedrich-Wilhelms-Universität Bonn, Abteilung für Neurochirurgie, Bonn, Deutschland
  • Erdem Güresir - Rheinische Friedrich-Wilhelms-Universität Bonn, Abteilung für Neurochirurgie, Bonn, Deutschland
  • Valeri Borger - Rheinische Friedrich-Wilhelms-Universität Bonn, Abteilung für Neurochirurgie, Bonn, Deutschland
  • Hartmut Vatter - Rheinische Friedrich-Wilhelms-Universität Bonn, Abteilung für Neurochirurgie, Bonn, Deutschland
  • Christoph Helmstaedter - Rheinische Friedrich-Wilhelms-Universität Bonn, Abteilung für Epileptologie, Bonn, Deutschland
  • Patrick Schuss - Rheinische Friedrich-Wilhelms-Universität Bonn, Abteilung für Neurochirurgie, Bonn, Deutschland
  • Motaz Hamed - Rheinische Friedrich-Wilhelms-Universität Bonn, Abteilung für Neurochirurgie, Bonn, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. sine loco [digital], 21.-24.06.2020. Düsseldorf: German Medical Science GMS Publishing House; 2020. DocV252

doi: 10.3205/20dgnc246, urn:nbn:de:0183-20dgnc2463

Published: June 26, 2020

© 2020 Ilic et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Objective: With regard to superior long-term disease control, anterior temporal lobectomies (ATL) as a supra-total resection regime have gained growing attention in surgery for temporal lobe tumors. However, aggressive temporal tumor resection might be accompanied by an impairment of a patient’s neurocognitive functioning. We therefore analyzed our institutional database with regard to postoperative changes in neurocognitive skills following surgical therapy of temporal-located low grade glioma depending on the extent of tumor resection

Methods: Between 1999 and 2018, 33 patients were surgically treated for temporal-located low-grade gliomas via ATL or lesionectomy in terms of gross-total resection (GTR) at the authors’ institution. Histopathological analysis revealed 7 grade-II pleomorphic xanthoastrocytoma, 19 grade-I pilocytic astrocatomas, 7 grade-II diffuse astrocytomas. Pre- and postsurgical neuropsychological examination included attention, language as well as verbal and figural memory functions. Language functions were assessed with the Token Test, and a phonemic verbal fluency task. Verbal and nonverbal memory was evaluated by the Verbaler Lern- und Merkfähigkeitstest and a revised five-trial version of the Diagnosticum für Cerebralschädigung, respectively.

Results: 14 patients were surgically treated by ATL, whereas GTR was performed in 19 patients. Analysis of attention revealed deterioration of preoperative functioning for 21% of patients in the GTR group compared to 20% in the ATL group (p=1.0). Respective values for verbal and nonverbal memory were 37% and 23% (p=0.5) as well as 15% and 32% (p=0.4). Postoperative language functions were worsened in 53% of patients with GTR compared to 62% of patients with ATL (p=0.8).

Conclusion: With regard to ATL and GTR as differing oncosurgical approaches that did not exhibit significant differences in the rates of postoperative neurocognitive impairment, ATL in terms of a supra-total resection strategy constitutes a safe surgical treatment option for temporal-located LGG.