gms | German Medical Science

71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

21.06. - 24.06.2020

Temporal muscle thickness as outcome predictor for patients with primary glioblastoma

Die Dicke des Temporalmuskels als Outcome-Prädiktor bei Patienten mit primärem Glioblastom

Meeting Abstract

  • presenting/speaker Julia Steinmann - Heinrich-Heine Universität, Klinik für Neurochirurgie, Düsseldorf, Deutschland
  • Franziska Staub-Bartelt - Heinrich-Heine Universität, Klinik für Neurochirurgie, Düsseldorf, Deutschland
  • Bernd Turowski - Heinrich-Heine Universität, Klinik für Radiologie, Düsseldorf, Deutschland
  • Hans-Jakob Steiger - Heinrich-Heine Universität, Klinik für Neurochirurgie, Düsseldorf, Deutschland
  • Hänggi Daniel - Heinrich-Heine Universität, Klinik für Neurochirurgie, Düsseldorf, Deutschland
  • Marion Rapp - Heinrich-Heine Universität, Klinik für Neurochirurgie, Düsseldorf, Deutschland
  • Michael Sabel - Heinrich-Heine Universität, Klinik für Neurochirurgie, Düsseldorf, Deutschland
  • Marcel Kamp - Heinrich-Heine Universität, Klinik für Neurochirurgie, Düsseldorf, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. sine loco [digital], 21.-24.06.2020. Düsseldorf: German Medical Science GMS Publishing House; 2020. DocBO-02

doi: 10.3205/20dgnc020, urn:nbn:de:0183-20dgnc0208

Published: June 26, 2020

© 2020 Steinmann et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.


Outline

Text

Objective: Patients with glioblastoma still have a very limited overall survival and reliable predictors for outcome are rare. Low skeletal muscle mass (sarcopenia) is known to be a poor prognostic factor for cancer patients. It is measured by CT lumbar skeletal muscle cross-sectional area (CSA). Recently a high correlation between CSA of lumbar skeletal muscle and temporal muscle thickness (TMT) was found. The aim of this study was to analyze a potential relation between temporal muscle thickness and outcome for patients with primary glioblastoma.

Methods: A retrospective analysis was performed for patients with primary glioblastoma and complete surgical resection assessed by an early postoperative MRI < 72h. Temporal muscle thickness was measured in preoperative 1.5 T-MRI scan in axial T1 sequences on both sides. Mean TMT was calculated and linear regression was performed.

Results: Analysis of the relation between TMT and outcome parameters under consideration of known predictors was performed in 49 patients with a mean age of 59 years (range 30 -83y). 16/49 (32%) patients were female and 33/49 (68%) male. Mean preoperative KPS was 90%. 21/47 (44%) patients had methylated MGMT promoter. Mean PFS was 13.1 months and mean OAS was 17 months. Mean TMT was 6.5mm (range 3.4 – 10.5mm). Linear regression showed, that TMT is an independent significant predictor of PFS (p < 0.01) and OAS (p < 0.01). An increase in every millimeter of TMT has an average survival benefit of 2.6 months

Conclusion: In the present cohort temporal muscle thickness (TMT) as a surrogate for the nutritional state of patients with primary glioblastoma is a significant predictor of outcome.