Article
Temporal muscle thickness as outcome predictor for patients with primary glioblastoma
Die Dicke des Temporalmuskels als Outcome-Prädiktor bei Patienten mit primärem Glioblastom
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Published: | June 26, 2020 |
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Objective: Patients with glioblastoma still have a very limited overall survival and reliable predictors for outcome are rare. Low skeletal muscle mass (sarcopenia) is known to be a poor prognostic factor for cancer patients. It is measured by CT lumbar skeletal muscle cross-sectional area (CSA). Recently a high correlation between CSA of lumbar skeletal muscle and temporal muscle thickness (TMT) was found. The aim of this study was to analyze a potential relation between temporal muscle thickness and outcome for patients with primary glioblastoma.
Methods: A retrospective analysis was performed for patients with primary glioblastoma and complete surgical resection assessed by an early postoperative MRI < 72h. Temporal muscle thickness was measured in preoperative 1.5 T-MRI scan in axial T1 sequences on both sides. Mean TMT was calculated and linear regression was performed.
Results: Analysis of the relation between TMT and outcome parameters under consideration of known predictors was performed in 49 patients with a mean age of 59 years (range 30 -83y). 16/49 (32%) patients were female and 33/49 (68%) male. Mean preoperative KPS was 90%. 21/47 (44%) patients had methylated MGMT promoter. Mean PFS was 13.1 months and mean OAS was 17 months. Mean TMT was 6.5mm (range 3.4 – 10.5mm). Linear regression showed, that TMT is an independent significant predictor of PFS (p < 0.01) and OAS (p < 0.01). An increase in every millimeter of TMT has an average survival benefit of 2.6 months
Conclusion: In the present cohort temporal muscle thickness (TMT) as a surrogate for the nutritional state of patients with primary glioblastoma is a significant predictor of outcome.