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69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

03.06. - 06.06.2018, Münster

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Deep brain stimulation of the centromedian-parafascicular nucleus affects apomorphine-induced alteration of striatal fast and medium spiking interneurons in a rat model

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  • Mesbah Alam - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland
  • Charlene Voigt - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland
  • Joachim K. Krauss - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland
  • Kerstin Schwabe - Medizinische Hochschule Hannover, Neurochirurgie, Hannover, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie. Münster, 03.-06.06.2018. Düsseldorf: German Medical Science GMS Publishing House; 2018. DocP163

doi: 10.3205/18dgnc504, urn:nbn:de:0183-18dgnc5047

Published: June 18, 2018

© 2018 Alam et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

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Objective: Striatal dysfunction has been related to the pathophysiology of tics in Tourette’s syndrome (TS). Deep brain stimulation (DBS) of the centromedian-parafascicular (CM-Pf) nucleus, which projects to the striatum, is used clinically to alleviate tics in TS. Apomorphine-induced deficient sensorimotor gating in rats has been used to model TS in rats. We recently showed that DBS of the rat CM-Pf may alleviate this behavioral change.We here investigated the effect of CM-Pf stimulation on single neuronal activity and oscillatory activity of striatal fast and medium spiking interneurons in this model.

Methods: We recorded dorsomedial striatum (DS-Str) medium spiny neurons (MSNs) and fast-spiking interneurons (FSIs) single unit (SU) activity together with local field potentials (LFPs) and sensory motor electro-corticogram (SMCtx- ECoG)under urethane anesthesia (1.4 g/kg, i.p.) in rats before and after apomorphine injection (1mg/kg). Thereafter, 60 sec CM-Pf-DBS (130 Hz, 100 µA current, with 120 µs biphasic square wave pulses) was applied and the neuronal activity recorded.

Results: While apomorphine had little effect on striatal single unit activity, CM-Pf DBS significantly increased the firing rate of putative FSIs and decreased the percentage of spikes in burst in the DM-Str. Injection of apomorphine increased the theta (4-8Hz) frequency coherences of SMCtx- ECoG with DM-Str-LFPs and the spike phase-locking to theta oscillatory activity, which was both reduced by CM-Pf DBS.

Conclusion: Our findings suggest that CM-Pf DBS modulates neuronal activity in the striatum in the context of a rat model showing traits of TS. These neuronal interactions allow to better understand the mechanisms of CM-Pf DBS on the striatum in deficient sensorimotor gating.