gms | German Medical Science

69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

03.06. - 06.06.2018, Münster

Article

Send article

Improving diagnostic accuracy of stereotactic biopsy by implementing amino acid PET: An intra-individual comparative study

Meeting Abstract

Search Medline for

  • Christina Hamisch - Uniklinik Köln, Allgemeine Neurochirurgie, Köln, Deutschland
  • Maximilian I. Ruge - Uniklinik Köln, Universitätsklinikum Bonn, Centrum für Integrierte Onkologie, Köln, Deutschland; Uniklinik Köln, Klinik für Stereotaxie und funktionelle Neurochirurgie, Köln, Deutschland
  • Daniel Rueß - Uniklinik Köln, Klinik für Stereotaxie und funktionelle Neurochirurgie, Köln, Deutschland
  • Norbert Galldiks - Forschungszentrum Jülich, Institut für Neurowissenschaften und Medizin, Jülich, Deutschland; Uniklinik Köln, Universitätsklinikum Bonn, Centrum für Integrierte Onkologie, Köln, Deutschland; RWTH Aachen, Klinik für Nuklearmedizin, Aachen, Deutschland; Uniklinik Köln, Klinik für Neurologie, Köln, Deutschland
  • Roland Goldbrunner - Uniklinik Köln, Universitätsklinikum Bonn, Centrum für Integrierte Onkologie, Köln, Deutschland; Uniklinik Köln, Klinik für Allgemeine Neurochirurgie, Köln, Deutschland
  • Stefan Grau - Uniklinik Köln, Klinik für Allgemeine Neurochirurgie, Köln, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie. Münster, 03.-06.06.2018. Düsseldorf: German Medical Science GMS Publishing House; 2018. DocV045

doi: 10.3205/18dgnc046, urn:nbn:de:0183-18dgnc0462

Published: June 18, 2018

© 2018 Hamisch et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

Text

Objective: To evaluate the diagnostic accuracy of MRI versus MRI/amino acid PET-guided stereotactic biopsy to obtain the correct histopathological diagnosis in suspected or recurrent glioma using open tumor resection (ORS) as a reference.

Methods: We retrospectively identified adult patients receiving stereotactic biopsy (SB) for suspected or recurrent glioma and subsequent ORS. Patient characteristics, histopathology and data on imaging techniques used for biopsy planning were evaluated. Histopathological diagnoses of biopsies were verified by the specimen obtained by subsequent ORS. Accuracy of MRI versus MRI/PET-guided SB for correct tumor classification as well as risk factors for under-grading or deviating diagnoses was calculated.

Results: Between January 2005 and 2017 100 consecutive adult patients (median age, 49; range, 22-86 years) were identified receiving SB for suspected or recurrent glioma and subsequent ORS. Biopsy planning was based on MRI alone in 64 patients (64%) and on MRI in combination with a amino acid PET in 36 patients (36%). The median time span between SB and ORS was 19 days. Diagnoses of SB and subsequent ORS were identical in 84 % (MRI alone) versus 97.2% (MRI+PET) (p=0.044). If glioma WHO grade II-IV was detected in both procedures, tumor grading was identical in 85.5% (MRI alone) versus 100% (MRI+PET), (p=0.014). The choice of imaging modality planning was the only factor significantly influencing diagnostic accuracy for both correct histology and grading.

Conclusion: Compared to SB planning on the basis of MRI alone, implementing amino acid PET significantly improved the diagnostic accuracy of SB in cerebral gliomas.