Article
Predictors for preoperative seizures in patients with skull base meningioma – a retrospective single center cohort study
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Authors
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Christian Rother
- Klinik für Neurochirurgie, Universitätsklinikum Tübingen, Germany
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Susan Noell
- Klinik für Neurochirurgie, Universitätsklinikum Tübingen, Germany
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Jens Schittenhelm
- Institut für Neuropathologie, Universitätsklinikum Tübingen, Germany
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Ghazaleh Tabatabai
- Klinik für Neurochirurgie, Universitätsklinikum Tübingen, Germany
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Marcos Tatagiba
- Klinik für Neurochirurgie, Universitätsklinikum Tübingen, Germany
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Marco Skardelly
- Klinik für Neurochirurgie, Universitätsklinikum Tübingen, Germany
| Published: | June 8, 2016 |
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Outline
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Objective: Patients with skull base meningioma develop seizures less often than patients with falx, convexity and parasagittal meningioma. However, there is a large variety of seizure rates within the group of skull base meningioma. In this study, we determined predictors for the occurrence of preoperative seizures in skull base meningioma.
Method: We performed a retrospective analysis of potential predictors for the occurrence of seizures in patients with skull base meningioma who underwent surgery between January 2009 and December 2012 at our institution. Potential risk factors for epileptogenicity, which included gender, age, tumor localization, tumor volume, WHO-grade and tumor histology were investigated by univariate and multivariate regression analyses.
Results: Seventeen of 305 patients (6%) with skull base meningioma presented with a history of at least one seizure. The highest seizure rates were observed in olfactory meningioma (18%), in male patients (10%) and sphenoid wing meningioma (9%). No seizure was observed in patients with tumors of the tuberculum sellae, of the planum sphnoidale and of the anterior clinoid process. In multivariate (n=174) regression only tumor location (p=0.005) had a significant effect on seizure occurrence; all other variables were not significant. Olfactory meningioma (RR 20.6, p = 0,0008) and meningioma of the sphenoid wing (RR 9.5, p = 0,011) showed a significant higher seizure rate compared to infratentorial meningioma.
Conclusions: Seizure occurrence of skull base meningioma depends only on tumor localization in our patient cohort. Olfactory meningioma demonstrates the highest seizure risk within all skull base meningiomas irrespectively of tumor volume or the impact of other covariates.
