Article
The pattern of spread and histopathology in multiple meningiomas
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Authors
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Woo Youl Jang
- Chonnam National University Hwasun Hospital, Korea
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Shin Jung
- Chonnam National University Hwasun Hospital, Korea
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Tae-Young Jung
- Chonnam National University Hwasun Hospital, Korea
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Kyung-Sub Moon
- Chonnam National University Hwasun Hospital, Korea
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In-Young Kim
- Chonnam National University Hwasun Hospital, Korea
| Published: | June 8, 2016 |
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Outline
Text
Objective: Multiple meningiomas are defined as at least two spatially separated meningiomas occurring simultaneously or more than two meningiomas arising sequentially from two clearly distinct regions. We reviewed the radiological findings, pathological diagnosis, and clinical outcome of multiple meningiomas.
Method: Between 2004 and 2015, 62 patients with multiple meningiomas underwent microsurgical resection in our institute. Multiple meningiomas were classified based on the pattern of spread. If the tumor is located adjacent to another tumor and the distance between tumors are less than 5 mm, the pattern of spread is defined as contiguous pattern. Histopathological study was performed, specially focused on the meninges between tumors.
Results: In 15 patients, tumors spread contiguously via the meninges pattern. Among them, 7 patients had separated noncontiguous meningiomas accompany with contiguous meningiomas. All of contiguous meningiomas showed same pathology. It is histopathological confirmed that there was the trail between tumors in contiguous meningiomas. Other 47 patients had noncontiguous meningiomas and the pathologies were different each other in 8 patients.
Conclusions: The pathogenesis of multiple meningiomas is different according to the spreading pattern. The contiguous meningiomas can spread more widely through the meninges and required radiological study should be performed more frequently than noncontiguous meningiomas.
