gms | German Medical Science

67th Annual Meeting of the German Society of Neurosurgery (DGNC)
Joint Meeting with the Korean Neurosurgical Society (KNS)

German Society of Neurosurgery (DGNC)

12 - 15 June 2016, Frankfurt am Main

Effects on neuropsychological outcome and quality of life in glioma patients with respect to WHO grading II and III

Meeting Abstract

Search Medline for

  • Timo Behm - Klinik für Neurochirurgie, Universitätsmedizin Göttingen, Germany
  • Claudia Frank - Klinik für Neurochirurgie, Universitätsklinikum der RWTH Aachen, Germany
  • Veit Rohde - Klinik für Neurochirurgie, Universitätsmedizin Göttingen, Germany

Deutsche Gesellschaft für Neurochirurgie. 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS). Frankfurt am Main, 12.-15.06.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. DocMO.03.03

doi: 10.3205/16dgnc010, urn:nbn:de:0183-16dgnc0109

Published: June 8, 2016

© 2016 Behm et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.


Outline

Text

Objective: Glioma patients suffer from deterioration of neurological and cognitive function as well as impact on psychological aspects and quality of life. Most analysis deal with groups of low-grade gliomas or high-grade gliomas compared to each other. Due to similar therapeutic strategies in combination with heterogeneous prognosis within these collectives, differentiation of effects caused by therapy or disease itself is difficult to handle. Based on these aspects in this study the effects on neurological and neuropsychological outcome were examined between glioma grade II and grade III.

Method: 44 patients with glioma grade II (n=25) or grade III (19) primarily treated by surgery were included. Pre- and postoperative testings contained token-test, d2-test, recurring-words-test, LGT-3, LPS-9/-10, Edinburgh-questionnaire, finger tapping test, TAP (alertness, dividing attention, go-/ no-go-test), FPI-R, HAMD, BDI and ALQI. Statistical correlation analysis and paired t-tests comparing pre- and postoperative results between the groups were retrospectively performed.

Results: Proportion of biopsy in grade II and III was 12% and 11%, of gross total resection 20% and 21%, of subtotal resection each 68%, respectively. Adjuvant radiotherapy was performed in 12% and 95%, respectively. Median time to postoperative testing was 8.5 months after surgery. Neurological deficits after treatment occurred frequently in grade III (58%) vs. grade II (20%, p=0.01). Preoperative neuropsychological deficits were present in items “ability to learn”, “dividing attention” and “memory performance” without any difference between the groups, in contrast grade III patients developed significant decrease of attentional performance after treatment. No significant differences were shown in pre- and postoperative quality of life and occurrence of depression, respectively.

Conclusions: Increased incidence of disorders in attentional performance after treatment seems to be related to worse WHO grade III and/or adjuvant therapy. As a constantly used ability, for patients this can lead to apparent restriction in daily life. In contrast occurrence of psychological diseases as well as quality of life is not directly influenced by WHO grade, different adjuvant therapy regimes and neurological or neuropsychological disorders.