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65th Annual Meeting of the German Society of Neurosurgery (DGNC)

German Society of Neurosurgery (DGNC)

11 - 14 May 2014, Dresden

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Comparative evaluation of the effects of cerebroventricular administration of albumin, mannitol, hypertonic NaCl, glycerin, and dextran on experimental brain edema

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  • Çagatay Önal - Inonu University, School of Medicine, Departments of Neurosurgery, Biochemistry, Pharmacology and Emergency Medicine, Malatya, Turkey
  • Tuncay Ates - Inonu University, School of Medicine, Departments of Neurosurgery, Biochemistry, Pharmacology and Emergency Medicine, Malatya, Turkey
  • Yusuf Türköz - Inonu University, School of Medicine, Departments of Neurosurgery, Biochemistry, Pharmacology and Emergency Medicine, Malatya, Turkey
  • Hakan Parlakpinar - Inonu University, School of Medicine, Departments of Neurosurgery, Biochemistry, Pharmacology and Emergency Medicine, Malatya, Turkey
  • Yilmaz Çigremis - Inonu University, School of Medicine, Departments of Neurosurgery, Biochemistry, Pharmacology and Emergency Medicine, Malatya, Turkey
  • Neslihan Yücel - Inonu University, School of Medicine, Departments of Neurosurgery, Biochemistry, Pharmacology and Emergency Medicine, Malatya, Turkey

Deutsche Gesellschaft für Neurochirurgie. 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Dresden, 11.-14.05.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. DocP 092

doi: 10.3205/14dgnc488, urn:nbn:de:0183-14dgnc4880

Published: May 13, 2014

© 2014 Önal et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective: The objective of the study is comparative evaluation of some selected pharmaceutical agents administered by stereotactic cerebroventricular route after experimental brain edema in rats.

Method: Six groups of rats, i.e. five experimental and one control, in similar conditions are used in the study. Standard brain trauma is produced by the weight drop method. In therapy groups, 2 microliters of therapeutic agent is administered 6, 12, and 24 hours after neurotrauma by cerebroventricular stereotactic route. The rats are sacrificed after 48 hours and brain tissue is extracted without extra damage. Analyses of GSH, NO, MDA, TNF-alpha, and IL-1-beta are performed on traumatic left hemispheres.

Results: GSH levels in all therapy groups except for the glycerin group revealed a statistically significant increase compared to control group. MDA and NO levels had different ratios of decrease, which showed a trend but without statistical significance. IL-1-beta showed a significant decrease in therapy groups, but TNF-alpha analysis revealed no difference between control and treatment groups.

Conclusions: Study results showed that brain edema and secondary brain injury due to oxidative stress might be decreased by the use of some selected pharmaceutical agents via cerebroventricular route on experimental basis. Additional studies with albumin, mannitol, hypertonic NaCl and dextran may be promising.