gms | German Medical Science

65th Annual Meeting of the German Society of Neurosurgery (DGNC)

German Society of Neurosurgery (DGNC)

11 - 14 May 2014, Dresden

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The prostate stem cell antigen (PSCA) expression is associated with malignancy of human meningiomas and shows a differential expression in primary and secondary malignant meningiomas

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  • Kathrin D Geiger - Bereich Neuropathologie, Institut für Pathologie, Klinikum der Technischen Universität Dresden; Institut für Pathologie, Klinikum der Johann Wolfgang Goethe Universität Frankfurt am Main
  • Tareq Juratli - Klinik für Neurochirurgie, Klinikum derTechnischen Universität Dresden
  • Matthias Kirsch - Klinik für Neurochirurgie, Klinikum derTechnischen Universität Dresden
  • Matthias Meinhardt - Bereich Neuropathologie, Institut für Pathologie, Klinikum der Technischen Universität Dresden
  • Achim Temme - Klinik für Neurochirurgie, Klinikum derTechnischen Universität Dresden
  • Gabriele Schackert - Klinik für Neurochirurgie, Klinikum derTechnischen Universität Dresden

Deutsche Gesellschaft für Neurochirurgie. 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Dresden, 11.-14.05.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. DocP 057

doi: 10.3205/14dgnc453, urn:nbn:de:0183-14dgnc4537

Published: May 13, 2014

© 2014 Geiger et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective: Prostate stem cell antigen (PSCA) is a homologue of the Thy1/Ly-6 family of glycosylphosphatidylinositol (GPI)-anchored cell surface antigens. We have recently demonstrated PSCA-expression in human gliomas associated with malignancy. The purpose of this study was to investigate the appearance of PSCA in human meningiomas and the evaluation of potential diagnostic or therapeutic uses.

Method: We analyzed a total of 110 cases including 100 human meningiomas and 10 normal control tissues from autopsy brains with regular leptomeninges for expression of PSCA by immunochemistry (IR) using the indirect peroxidase technique on tissue multi arrays (TMA) of paraffin-embedded specimen and by using a semiquantitative evaluation system. Chi-square test was employed for statistical evaluation.

Results: We found PSCA mostly absent in normal brain tissues, except for some Purkinje cells of the cerebellum and only minimally expressed in regular leptomeninges. PSCA-IR was detectable in 70% of all meningiomas (>0,5 Score value). 25% of the meningiomas WHO grade I and 40% of meningiomas WHO grade II showed slight to moderate expression of PSCA by immunochemistry (IR). Strong PSCA IR was seen in 20% of atypical meningiomas WHO grade II and in 70% of the anaplastic meningiomas WHO grade III. However, in primary malignant meningiomas 85% showed strong PSCA-IR (n=12). In secondary malignant meningiomas only 50% showed increased PSCA-IR (n=16). This difference was significant.

Conclusions: Association of PSCA with malignancy of meningiomas was significant and may provide an additional diagnostic tool for the histological classification of meningiomas.