gms | German Medical Science

62nd Annual Meeting of the German Society of Neurosurgery (DGNC)
Joint Meeting with the Polish Society of Neurosurgeons (PNCH)

German Society of Neurosurgery (DGNC)

7 - 11 May 2011, Hamburg

Malignant peripheral nerve sheath tumors (MPNST) – is there a connection between clinical course and immunohistochemical findings?

Meeting Abstract

  • C. Heinen - Neurochirurgische Klinik der Universität Ulm / Günzburg
  • T. Schmidt - Neurochirurgische Klinik der Universität Ulm / Günzburg
  • U. Bäzner - Neurochirurgische Klinik der Universität Ulm / Günzburg
  • G. Antoniadis - Neurochirurgische Klinik der Universität Ulm / Günzburg
  • T. Kretschmer - Klinik für Neurochirurgie, Evangelisches Krankenhaus Oldenburg
  • R. Wirtz - Neurochirurgische Klinik der Universität Ulm / Günzburg
  • R. König - Neurochirurgische Klinik der Universität Ulm / Günzburg
  • A. Scheuerle - Institut für Neuropathologie der Universität Ulm
  • M.T. Pedro - Neurochirurgische Klinik der Universität Ulm / Günzburg

Deutsche Gesellschaft für Neurochirurgie. Polnische Gesellschaft für Neurochirurgen. 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH). Hamburg, 07.-11.05.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. DocP 058

doi: 10.3205/11dgnc279, urn:nbn:de:0183-11dgnc2792

Published: April 28, 2011

© 2011 Heinen et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: MPNST is a rare and very aggressive soft tissue tumor entitiy. Recently, new insights into molecular mechanisms became known and new classifications were proposed. We tried to apply these findings to our own MPNST patients in order to understand if the clinical course was influenced.

Methods: We retrospectively analyzed 22 patients with MPNST treated in our hospital between 1993 and 2010. Association with neurofibromatosis type 1 (NF1), clinical presentation, date of surgery, imaging, histological and immunohistochemical data were assessed. Furthermore, following treatment, formation of metastasis and tumor-free survival time was recorded.

Results: Most patients presented with pain in the affected area (20/22), 18 suffered from weakness and 19 from hypesthesias. Tumors arose in the distal part of the extremities in only 3 cases. Out off 22 patients, 11 had NF1, 6 of which had already died. Out of the 11 non-NF1-affected patients, 4 died. Patients with elevated Mib-1 and Ki-67 indices tended to have a poorer prognosis as well as patients displaying vast tumor necrosis. Expression of S100 was not necessarily associated with a better survival rate.

Conclusions: In our series, outcome seemed to depend on an association with NF1, presence of pain and extent of loss of function. Elevated Ki 67 and MiB1 indices showed correlation with a higher aggressiveness. Further efforts are necessary to understand the value of tumor markers in MPNST to predict the individual clinical course.