gms | German Medical Science

57th Annual Meeting of the German Society of Neurosurgery
Joint Meeting with the Japanese Neurosurgical Society

German Society of Neurosurgery (DGNC)

11 - 14 May, Essen

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Vascular endothelial growth factor plasma levels are significantly elevated in patients with cerebral arteriovenous malformations

Vascular Endothelial Growth Factor Plasma Spiegel sind bei Patienten mit arterio-venösen Malformationen signifikant erhöht

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  • corresponding author I.E. Sandalcioglu - Universitätsklinikum Essen, Neurochirurgische Klinik und Poliklinik, Essen
  • D. Wende - Universitätsklinikum Essen, Neurochirurgische Klinik und Poliklinik, Essen
  • A. Eggert - Universitätsklinikum Essen, Abteilung Hämatologie/Onkologie und Endokrinologie, Zentrum für Kinder und Jugendmedizin, Essen
  • T. Gasser - Universitätsklinikum Essen, Neurochirurgische Klinik und Poliklinik, Essen
  • D. Müller - Universitätsklinikum Essen, Institut für Medizinische Informatik, Biometrie und Epidemiologie, Essen
  • U. Roggenbuck - Universitätsklinikum Essen, Institut für Medizinische Informatik, Biometrie und Epidemiologie, Essen
  • H. Wiedemayer - Universitätsklinikum Essen, Neurochirurgische Klinik und Poliklinik, Essen
  • D. Stolke - Universitätsklinikum Essen, Neurochirurgische Klinik und Poliklinik, Essen

Deutsche Gesellschaft für Neurochirurgie. Japanische Gesellschaft für Neurochirurgie. 57. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie. Essen, 11.-14.05.2006. Düsseldorf, Köln: German Medical Science; 2006. DocP 10.148

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2006/06dgnc365.shtml

Published: May 8, 2006

© 2006 Sandalcioglu et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Objective: Since growth and de novo generation of cerebrovascular malformations were demonstrated, a strictly congenital model as unique factor in the pathogenesis of cerebral arteriovenous malformations (AVMs) cannot be further supported. Vascular endothelial growth factor (VEGF) has previously been demonstrated to be highly expressed in AVMs by immunohistochemical methods. However, systemic VEGF levels have not been analysed previously. This study aimed to investigate VEGF plasma concentrations as a possible plasma marker for neovascularization in patients with cerebral AVMs compared to healthy controls.

Methods: The study included 17 patients with cerebral AVMs and 40 healthy controls. VEGF plasma concentrations were measured by a specific enzyme immunoassay.

Results: VEGF plasma concentrations were significantly higher in patients with cerebral AVMs (mean 140.9 pg/ml, SD 148.5 pg/ml and median 63.0 pg/ml) compared to a healthy control group (mean 44.7 pg/ml, SD 36.4 pg/ml and median 35.0 pg/ml), p=0.0003.

Conclusions: Our findings suggest that VEGF plasma concentrations might play a role in the pathogenesis of cerebral AVMs. Further studies are necessary and would contribute to an improved understanding of the pathogenesis of cerebral AVMs.