gms | German Medical Science

56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
3èmes journées françaises de Neurochirurgie (SFNC)

Deutsche Gesellschaft für Neurochirurgie e. V.
Société Française de Neurochirurgie

07. bis 11.05.2005, Strasbourg

Radiosurgery for nonfunctioning pituitary adenomas

Radiochirurgische Behandlung von hormoninaktiven Hypophysenadenomen

Meeting Abstract

Search Medline for

  • corresponding author A. Muacevic - Deutsches Gamma Knife Zentrum, München
  • E. Uhl - Neurochirurgische Klinik, Ludwig-Maximilians-Universität, München
  • B. Wowra - Deutsches Gamma Knife Zentrum, München

Deutsche Gesellschaft für Neurochirurgie. Société Française de Neurochirurgie. 56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC). Strasbourg, 07.-11.05.2005. Düsseldorf, Köln: German Medical Science; 2005. Doc09.05.-07.06

The electronic version of this article is the complete one and can be found online at:

Published: May 4, 2005

© 2005 Muacevic et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.




The efficacy of gamma knife radiosurgery(GKS) for residual nonfunctioning pituitary adenomas (NPAs) is assessed.


60 patients with NPA were treated by GKS. Complete neurological and endocrinological follow-up information was available for 51 patients. Follow-up examinations included stereotactic magnetic resonance imaging for sequential measurements of the NPA volume.


The median dose to the tumor margin was 16.5 Gy (range 11–20 Gy). The mean prescription isodose was 50% (range 45–75%). All patients underwent surgery for NPA before GKS. Fractionated radiotherapy was not applied. Median follow-up after GKS was 21,7 months. The actuarial recurrence-free survival was 95% after three years with respect to a single GKS and 100% for patients who underwent repeated GKS. No neurological side effects were detected. Two patients developed new partial pituitary insufficiency after radiosurgery.


Postoperative GKS for residual or recurrent small fragments of NPAs is an effective and safe treatment option. The follow-up examination for NPAs should include tumor volumetric analysis.