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55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

25. bis 28.04.2004, Köln

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Contrast-enhanced harmonic imaging sonography: A method for intraoperative relative cerebral blood flow measurement

Kontrastmittelverstärkter Harmonic-imaging-Ultraschall: eine Methode zur Messung des relativen zerebralen Blutflusses

Meeting Abstract

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  • corresponding author Christine Lindner - Neurochirurgische Klinik der Universität Würzburg, Würzburg
  • J. Broscheit - Anästhesiologische Klinik der Universität Würzburg, Würzburg
  • M. Woydt - Neurochirurgische Klinik der Universität Würzburg, Würzburg

Deutsche Gesellschaft für Neurochirurgie. Ungarische Gesellschaft für Neurochirurgie. 55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie. Köln, 25.-28.04.2004. Düsseldorf, Köln: German Medical Science; 2004. DocP 10.103

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgnc2004/04dgnc0386.shtml

Published: April 23, 2004

© 2004 Lindner et al.
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Outline

Text

Objective

Different new ultrasound techniques are available to measure tissue perfusion. Ultrasound has the capability to be used intraoperatively and scanning a wide area of brain tissue. Therefore this study evaluates CE HI (=contrast-enhanced harmonic imaging) ultrasound to measure relative cerebral blood flow (=rCBF) intraoperatively in an animal model.

Methods

5 adult sheep were craniotomized , two Laser-Doppler-Flow (=LDF) probes and a linear 7.5MHz ultrasound probe were placed on the dura. During normoventilation 4 times 2ml of undiluted Sonovue® (Bracco) were infused as a bolus via a femoral venous catheter with and without occlusion of the carotid arteries. Additionally 4 sheep were hypoventilated. Relative cerebral blood flow was calculated in different regions-of-interest by using time-intensity-curves. Due to the low ultrasound energy in this method, no CE destruction occurred. The area-under-the-curve (=AUC) intensity gives the relative cerebral blood volume (=rCBV) which was divided by the time gap between the 50% maximum intensity during in- and outflow giving the mean transit time (=MTT) [rCBF=rCBV / MTT]. Inter- and intraobserver varibility, changes of rCBF during carotid occlusion, reperfusion and hypoventilation were calculated and correlated to LDF for both hemispheres.

Results

During carotid occlusion, a significant reduction of rCBF was found for the left hemisphere (p<0,05) and significant increase in rCBF (p<0,05) for reperfusion for both sides in the paired t-test. During hypoventilation we found a significant increasing of rCBF (p<0,05) for both hemispheres. Good correlation to flow measurements in LDF was found.

Conclusions

Perfusion measurement with contrast-enhanced HI ultrasound proved to be a method for calculation of rCBF during different perfusion stages, which can be used during operation.