gms | German Medical Science

55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e. V. (DGNC)
1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

25. bis 28.04.2004, Köln

Hypoxia inducible factor and vascular endothelial growth factor is expressed more frequently in embolized than in non-embolized cerebral arteriovenous malformations

HIF und VEGF werden häufiger in embolisierten als in nicht embolisierten AVMen exprimiert

Meeting Abstract

  • corresponding author Ulrich Sure - Neurochirurgische Klinik, Philipps-University, Marburg
  • L. Benes - Neurochirurgische Klinik, Philipps-University, Marburg
  • S. Bien - Abteilung für Neuroradiologie, Philipps-University, Marburg
  • O. Bozinov - Neurochirurgische Klinik, Philipps-University, Marburg
  • H. Bertalanffy - Neurochirurgische Klinik, Philipps-University, Marburg

Deutsche Gesellschaft für Neurochirurgie. Ungarische Gesellschaft für Neurochirurgie. 55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie. Köln, 25.-28.04.2004. Düsseldorf, Köln: German Medical Science; 2004. DocP 02.11

The electronic version of this article is the complete one and can be found online at:

Published: April 23, 2004

© 2004 Sure et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.




In previous studies, we documented a marked neoangiogenesis and endothelial proliferation in cerebral arteriovenous malfomations (AVMs) that were embolized prior to surgery when compared to those which were not embolized. We hypothesized that embolization causes a local hypoxia that promotes neoangiogenesis as a possible pathomechanism. To support this hypothesis, we now examine the angiogenesis-related proteins in a larger collective of patients. Additionally, we have investigated the hypoxia inducible factor-1 (HIF-1) as a possible protein operative during neoangiogenesis of cerebral AVMs.


The paraffin-embedded specimens of 56 AVMs obtained from surgical resection and 14 brain tissue controls were immunohistochemically stained with antibodies to PCNA, MIB-1, VEGF, Flk1 and HIF-1 by standard protocols.


In AVMs treated with embolization prior to surgery (n=35, 63%), the expression of HIF-1 (p=0,0101) and VEGF (p=0,0007) was significantly higher (Fisher’s exact test) when compared to patients who did not have prior endovascular treatment. Differences in the expression of Flk-1 (p=0.0798) and PCNA (p=0,0423) were in the same direction, but not significant when corrected for multiple testing.


Our results provide circumstantial evidence that a partial occlusion of cerebral AVMs might induce local hypoxia related neoangiogenesis. To support this data future animal studies need to be carried out.