Article
Prevention of S epidermidis endophthalmitis by different moxifloxacin prophylaxis routes
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Published: | April 5, 2013 |
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Purpose: To investigate the ability to prevent post-operative endophthalmitis (POE) by different moxifloxacin prophylaxis protocols.
Methods: A reproducible challenge POE model was developed in New Zealand White rabbits eyes by injection of 0.1 ml of 5*105 CFUs of staphylococcus coagulase negative (ATCC 155) after lens removal and IOL implantation. Twenty eight New Zealand rabbit’s eyes were divided for 4 groups after lens removal. Group A: implantation of C-Flex IOLs, Group B: implantation of C-Flex IOLs and intracameral injection of 0.1 ml 100 mcg/ml moxifloxacin at the end of surgery, Group C: implantation of C- Flex IOLs that were pre-soaked in moxifloxacin 15 minutes before the implantation, Group D: implantation of C- Flex IOLs that were pre-soaked in moxifloxacin 15 minutes before the implantation and intracameral injection of 0.1 ml 100 mcg/ml moxifloxacin at the end of surgery. Twenty four hours later the eyes were evaluated for development of POE.
Results: Group A: 7/7 eyes (100%) has developed POE, Group B: 5/7 of the eyes (71%) has developed POE, Group C: 4/7 of the eyes (57%) has developed POE (p=0.057), Group D: 2/7 of the eyes (29%) has developed POE (p=0.005).
Conclusion: The combination of short pre-soaking of the C-Flex IOL in moxifloxacin before implantation and intracameral moxifloxacin injection showed the best prevention rate of POE.