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27. Kongress der Deutschsprachigen Gesellschaft für Intraokularlinsen-Implantation, Interventionelle und Refraktive Chirurgie (DGII)

Gesellschaft für Intraokularlinsen-Implantation, Interventionelle und Refraktive Chirurgie (DGII)

11.04. - 13.04.2013, Heidelberg

Prevention of S epidermidis endophthalmitis by different moxifloxacin prophylaxis routes

Meeting Abstract

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  • Guy Kleinmann - Rehovot/IL
  • O. S. Yovel - Rehovot/IL
  • S. Ben-Eliahu - Rehovot/IL

Deutschsprachige Gesellschaft für Intraokularlinsen-Implantation, Interventionelle und Refraktive Chirurgie. 27. Kongress der Deutschsprachigen Gesellschaft für Intraokularlinsen-Implantation, Interventionelle und Refraktive Chirurgie (DGII). Heidelberg, 11.-13.04.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. Doc13dgii024

doi: 10.3205/13dgii024, urn:nbn:de:0183-13dgii0248

Published: April 5, 2013

© 2013 Kleinmann et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.


Outline

Text

Purpose: To investigate the ability to prevent post-operative endophthalmitis (POE) by different moxifloxacin prophylaxis protocols.

Methods: A reproducible challenge POE model was developed in New Zealand White rabbits eyes by injection of 0.1 ml of 5*105 CFUs of staphylococcus coagulase negative (ATCC 155) after lens removal and IOL implantation. Twenty eight New Zealand rabbit’s eyes were divided for 4 groups after lens removal. Group A: implantation of C-Flex IOLs, Group B: implantation of C-Flex IOLs and intracameral injection of 0.1 ml 100 mcg/ml moxifloxacin at the end of surgery, Group C: implantation of C- Flex IOLs that were pre-soaked in moxifloxacin 15 minutes before the implantation, Group D: implantation of C- Flex IOLs that were pre-soaked in moxifloxacin 15 minutes before the implantation and intracameral injection of 0.1 ml 100 mcg/ml moxifloxacin at the end of surgery. Twenty four hours later the eyes were evaluated for development of POE.

Results: Group A: 7/7 eyes (100%) has developed POE, Group B: 5/7 of the eyes (71%) has developed POE, Group C: 4/7 of the eyes (57%) has developed POE (p=0.057), Group D: 2/7 of the eyes (29%) has developed POE (p=0.005).

Conclusion: The combination of short pre-soaking of the C-Flex IOL in moxifloxacin before implantation and intracameral moxifloxacin injection showed the best prevention rate of POE.