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130. Kongress der Deutschen Gesellschaft für Chirurgie

Deutsche Gesellschaft für Chirurgie

30.04. - 03.05.2013, München

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Liver Transplantation from Donors with Past History of Malignancy: a Single Center Experience

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  • Tamas Benkö - Universitätsklinikum Essen, Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Essen
  • Sonia Radünz - Universitätsklinikum Essen, Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Essen
  • Mark Banysch - Universitätsklinikum Essen, Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Essen
  • Fuat Saner - Universitätsklinikum Essen, Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Essen
  • Andreas Paul - Universitätsklinikum Essen, Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Essen
  • Jürgen Treckmann - Universitätsklinikum Essen, Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Essen

Deutsche Gesellschaft für Chirurgie. 130. Kongress der Deutschen Gesellschaft für Chirurgie. München, 30.04.-03.05.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. Doc13dgch727

doi: 10.3205/13dgch727, urn:nbn:de:0183-13dgch7278

Published: April 26, 2013

© 2013 Benkö et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Introduction: The demand for transplantable organs exceeds donor supply. Transplantation of organs from donors with past history of malignancy is controversial, and the transmission of cancer in liver transplant recipients has not been sufficiently determined.

Material and methods: From 2002 until 2012, 47 livers from donors with a past history of cancer were transplanted at the University Hospital Essen. Donor and recipient data, type of cancer, tumor-free interval at organ procurement and follow-up data were collected and analyzed.

Results: Nine tumor sites [genitourinary (n=19), brain (n=14), skin (n= 2), breast (n=5), thyroid (n=2), lung (n=2), acute myeloid leukemia (n=1), larynx (n=1), liver (n=1)] were diagnosed in the 47 donors with a history of cancer. The majority (68%) of donors had tumor-free intervals of 5 years or less. During median follow up of 520 days (31-2840) no recipients of organs from donors with malignancy in history developed donor-derived cancer.

Conclusion: Liver transplantation with organs from donors with a past medical history of cancer is feasible and the risk of donor-transmitted tumor seems to be small. The careful selection of donors remains mandatory and can expand the donor pool.