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130. Kongress der Deutschen Gesellschaft für Chirurgie

Deutsche Gesellschaft für Chirurgie

30.04. - 03.05.2013, München

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Colorectal Signet Ring Cell Carcinoma: Incidence and Epidemiological Distribution at a Tertiary Care Center

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  • Tarkan Jäger - Paracelsus Medical University, Department of Surgery, Salzburg
  • Selina Buchner - Paracelsus Medical University, Department of Surgery, Salzburg
  • Daniel Neureiter - Paracelsus Medical University, Department of Surgery, Salzburg
  • Adam Dinnewitzer - Paracelsus Medical University, Department of Surgery, Salzburg
  • Dietmar Öfner - Paracelsus Medical University, Department of Surgery, Salzburg

Deutsche Gesellschaft für Chirurgie. 130. Kongress der Deutschen Gesellschaft für Chirurgie. München, 30.04.-03.05.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. Doc13dgch672

doi: 10.3205/13dgch672, urn:nbn:de:0183-13dgch6720

Published: April 26, 2013

© 2013 Jäger et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

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Introduction: Primary colorectal signet ring cell carcinoma (SRCC) is a rare finding with an incidence of 0.9% to 4 %. This entity is characterized by an aggressive tumor biological behavior and is associated with a worse outcome compared to mucinous or adenocarcinoma. SRCC are defined as carcinoma cells with ≥ 50% intracellular mucin of the tumor mass displacing the nuclei to the side. Tumor cells comprising ≥ 50% extracellular mucin of the tumor mass are classified as mucinous carcinomas. The aim of this study was to analyze the incidence and epidemiological distribution of SRCC in colorectal cancer patients at our tertiary care unit.

Material and methods: Data were collected prospectively within a proprietary colorectal cancer database. 759 consecutive patients with primary colorectal cancer from 2003 to 2010 were analyzed and investigated for clinicopathological and epidemiological parameters of SRCC. Microsatellite instability (MSI) and immunohistochemical examinations are in work and will be presented.

Results: Of the 759 patients 649 (85.7%) were adenocarcinoma, 101 (13.3%) mucinous and 9 (0.9%) SRCC. Nine SRCC patients (female 56%) with a median age of 66 (range 38 – 76) were analyzed. Tumor localization: right colon (n=5), left colon (n=2) and rectum (n=2). All SRCC presented at later stage (UICC III: n=5, UICC IV: n=4). 45% had metastasis at the time of diagnosis. Three died within one year after diagnosis.

Conclusion: Colorectal SRCC's are characterized by advanced stage at diagnosis. Predilection site in our cohort was the right colon. Because of the aggressive biological behavior of SRCC a more radical surgical approach, modified chemotherapy trials and a closer follow up are necessary.