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123. Kongress der Deutschen Gesellschaft für Chirurgie

Deutsche Gesellschaft für Chirurgie

02. bis 05.05.2006, Berlin

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The Effects of Tolerance Induction on the Actions of Interferon-γ on Cardiac Allografts

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  • corresponding author R. Hoerbelt - Klinik für Allgemein- und Thoraxchirurgie der Universität Giessen, Deutschland
  • T. Shoji - Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  • W. Padberg - Klinik für Allgemein- und Thoraxchirurgie der Universität Giessen, Deutschland
  • D.H. Sachs - Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  • J.C. Madsen - Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

Deutsche Gesellschaft für Chirurgie. 123. Kongress der Deutschen Gesellschaft für Chirurgie. Berlin, 02.-05.05.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06dgch4521

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dgch2006/06dgch372.shtml

Published: May 2, 2006

© 2006 Hoerbelt et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Einleitung: It is well known that Interferon-γ (IFN-γ) not only plays a critical role in antigen-dependent but in antigen-independent tissue injury, but it is not clear how tolerance induction affects the actions of IFN-γ in the transplant setting. To address this question, we compared the effects of IFN-γ on porcine recipients of syngeneic, rejecting and tolerant heart transplants.

Material und Methoden: IFN-γ was perfused continuously into the left anterior descending artery of hearts transplanted into three groups of MHC inbred miniature swine, each treated with a 12-day course of CyA. Group 1 recipients received a near syngeneic heart, Group 2 recipients received a class I disparate heart and Group 3 recipients were cotransplanted with a class I disparate heart and kidney, which uniformly induces tolerance to both grafts. An additional, group of animals were not transplanted but received intracoronary IFN-γ infusion into their native hearts.

Ergebnisse: IFN- perfusion not only accelerated the acute rejection of class I disparate hearts (mean survival time = 19±7.21 vs. 38±8.19, p=0.025) but caused near syngeneic, heart transplants, which otherwise survive indefinitely, to reject within 35 days (n=3) .In contrast, IFN-γ perfusion had no demonstrable effects on either interstitial rejection, the development of vascular lesions or graft survival in tolerant heart plus kidney allograft recipients (n=4) or in autologous hearts (n=2).

Schlussfolgerung: These results suggest that tolerance induction mitigates the damaging effects of IFN-γ itself and that the beneficial effects of tolerance induction on acute and chronic rejection may extend to antigen-independent factors like ischemia/reperfusion injury.