gms | German Medical Science

GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNOKHC)

ISSN 1865-1038

Gigant cell lesions of the nasal cavity and sinuses


  • corresponding author Wieslaw Golabek - Otolaryngology Dept., Lublin, Poland
  • Kamal Morshed - Otolaryngology Dept., Lublin, Poland
  • Agnieszka Fronczek - Pathology Dept., Lublin, Poland
  • Ewa Golabek - Radiology Dept., Lublin, Poland

GMS Curr Posters Otorhinolaryngol Head Neck Surg 2009;5:Doc65

doi: 10.3205/cpo000469, urn:nbn:de:0183-cpo0004693

Published: April 16, 2009

© 2009 Golabek et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Giant cell tumours (osteoclastoma) are very uncommon neoplasms in the facial skeleton. Their usual clinical presentation is in the long bones. The differential diagnosis of giant cell tumour (GCT) in the facial skeleton includes giant cell granuloma (GCG), brown tumour, nonossifying fibroma, chondroblastoma and odontogenic cyst. It can be very difficult to differentiate histologically three lesions: giant cell tumour, giant cell granuloma and brown tumour related to hyperparathyroidism

One case of GCT and five cases of GCG are presented. Four men and one woman aged 14–68 years had GCG that occupied the maxillary sinus and nasal cavity. Clinical symptoms included swelling of the cheek, nasal obstruction and facial pain. CT well demonstrated extension of the lesion and erosion of the alveolar process and sinus walls. The lesions were removed using sublabial approach with disease free 4–15 years follow up.

A 16 years old boy presented with unilateral blindness, headache and biopsy result: giant cell tumour. Imaging radiography revealed involvement of the sphenoid sinus, orbit apex and middle cranial cavity bilaterally. We removed the tumour subtotally using subcranial approach. A year later he was operated again in another institution and this resulted with bilateral blindness and temporary haemiplegia.

Concluding, CT and MRI well demonstrate giant cell lesions and the goal of surgical treatment is radical removal. This might not always be possible when the giant cell tumour invades the skull base.