gms | German Medical Science

GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNOKHC)

ISSN 1865-1038

Article

Send article

Cholesteatoma – the Neoangiogenesis in Adults and Children

Poster

Search Medline for

  • corresponding author Pavel Dimov - Univ.Clinic ORL, Stara Zagora, Bulgarien
  • Tatyana Vlaykova - Dept. of Biochemistry, Stara Zagora, Bulgarien
  • May Gulubova - Dept. of General and Clinical Pathology, Stara Zagora, Bulgarien
  • Georgi Edrev - Medical Faculty, Trakia University, Stara Zagora, Bulgarien
  • Anna Michova - National Transport Hospital, Sofia, Bulgarien

GMS Curr Posters Otorhinolaryngol Head Neck Surg 2007;3:Doc78

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/journals/cpo/2007-3/cpo000343.shtml

Published: April 25, 2007

© 2007 Dimov et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Abstract

Оbjective: The aim of the current study was: to detect the presence of large and newly form small blood vessels in chronic inflammation of cholesteatoma and to evaluate the role of VEGF and CD-31 in triggering of angiogenesis in chronic inflammation of cholesteatoma in adults and children

Material & Methods: The CD-31- positive blood vessels and the level of expression of VEGF were determined by immunohistochemistry 16 archival biopsies which from patients with adults cholesteatoma and 5 patients with pediatric cholesteatoma

Results: CD31-positive blood vessels in the granulation tissue of cholesteatoma were more numerous than the vessels in the adjacent normal skin of the auditory meatus; VEGF-positive blood vessels in the granulation tissue cholesteatoma are more numerous that the vessels in the adjacent normal skin of the auditory meatus.

Conclusion: The observed increased angiogenesis in granulation tissue of cholesteatoma might be triggered by the increased expression of VEGF which is secreted by many structures and cells in perimatrix of cholesteatoma.

The studies characteristics of the active angiogenesis were markedly enhanced in the biopsies from congenital cholesteatoma form. The results suggest the important role of angiogenesis in the growth of cholesteatoma and in aggressiveness of congenital pediatric type

Key words: Cholesteatoma, Adults, Children, Angiogenesis, VEGF, CD-31

Keywords: Cholesteatoma, Adults, Children, Angiogenesis, VEGF, CD-31