Artikel
A serologic diagnose and study on SARS antibody of four newly occurred confirmed SARS cases in 2003-2004 in Guangdong, P.R.China
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Autoren
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Ling Fang
- Microbiology Institute , Centers for Disease Control and Prevention of Guangdong Province, P.R. China
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Hui Li
- Microbiology Institute , Centers for Disease Control and Prevention of Guangdong Province, P.R. China
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Li-mei Diao
- Microbiology Institute , Centers for Disease Control and Prevention of Guangdong Province, P.R. China
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Hui-qiong Zhou
- Microbiology Institute , Centers for Disease Control and Prevention of Guangdong Province, P.R. China
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Ji-cheng Huang
- Microbiology Institute , Centers for Disease Control and Prevention of Guangdong Province, P.R. China
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Zhuo-yue Wan
- Microbiology Institute , Centers for Disease Control and Prevention of Guangdong Province, P.R. China
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Jin-yan Lin
- Microbiology Institute , Centers for Disease Control and Prevention of Guangdong Province, P.R. China
| Veröffentlicht: | 26. Mai 2004 |
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Gliederung
Text
Background: It has passed about half a year since last outbreak of severe acute respiratory syndrome(SARS).The reemergence of the first suspected SARS case in Guangzhou soon aroused much attention all over the world. From suspicious to suspected to confirmed of the four cases, the serologic diagnose in our lab had played an important role.
Objective: To confirm the four newly occurred SARS cases in Guangdong, China in 2003-2004 and to analyze the antibody response and the developing history of the SARS-IgM and SARS-IgG antibody of these cases .
Methodology: A series of serum specimen of the four newly occurred SARS cases were collected. SARS-IgM and SARS-IgG were detected by ELISA. The results were presented by figures.
Results: SARS-IgM and SARS-IgG antibody of the first three cases were seropositive since day 6-8 after onset of illness. And had a 4-fold rise in SARS-IgG and/or SARS-IgM antibody titer 2-4 days afterwards. The titer of SARS-IgM and SARS-IgG antibody increased progressively and peaked at about ten days after onset of illness. After maintaining several days they decreased. SARS-IgM can be detected in only the original sample of the third case. SARS-IgG antibody of the fourth case had seroconversion later than the first three cases.
Conclusion: Our SARS surveillance system is sensitive and accurate. The four cases have all infected SARS-CoV. But the developing history of SARS antibody was different from that of the outbreak in Guangdong Province in early 2003 .The antibody to SARS-CoV emerged earlier and increased fast in titer this time. Some scientists brought up the possibility of previous infection of the first confirmed SARS case, it is worth researching.
