gms | German Medical Science

26. Jahrestagung der Deutschen Retinologischen Gesellschaft

Deutsche Gesellschaft für Retinologie

27.09.2013, Hamburg

Inflammation and degenerative retinal diseases

Meeting Abstract

Suche in Medline nach

  • Thomas Langmann - Cologne, Germany

Retinologische Gesellschaft. 26. Jahrestagung der Retinologischen Gesellschaft. Hamburg, 27.-27.09.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. Doc13rg02

doi: 10.3205/13rg02, urn:nbn:de:0183-13rg024

Veröffentlicht: 20. August 2013

© 2013 Langmann.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Hereditary retinal dystrophies are characterized by progressive retinal degeneration. Similar degenerative processes are evident in multifactorial and complex retinal disorders including age-related macular degeneration. To understand early triggers of these mechanisms, genetic and experimental mouse models have been developed that mimic human retinal degeneration. In most of these models, early chronic activation of the innate immune system has been documented. This process involves the complement cascade and microglial cells as sensors and effectors of the retinal immune response. Current evidence suggests that the genetic predisposition and individual factors like age or diet critically influence the immune homeostasis in the retina. Based on their effectiveness, innate immune mechanisms are thought to support or even provoke retinal degeneration. This talk will summarize the recent progress in understanding the role of innate immunity in retinal degenerative diseases and highlights the retinal immunopathology as potential therapeutic target to prevent vision loss.