gms | German Medical Science

10th Munich Vascular Conference

01.-03.12.2021, online

Chronic Venous Insufficiency Symptoms and Inflammatory Markers

Meeting Abstract

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10th Munich Vascular Conference. sine loco [digital], 01.-03.12.2021. Düsseldorf: German Medical Science GMS Publishing House; 2021. Doc15

doi: 10.3205/21mac15, urn:nbn:de:0183-21mac158

Veröffentlicht: 22. Dezember 2021

© 2021 Karam et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe



Background: The pathophysiology of venous symptoms in chronic venous insufficiency is still unclear. We tried to investigate a potential correlation between the inflammatory markers and VEGF in the wall of the greater saphenous vein and chronic venous insufficiency symptoms.

Methods: 40 great saphenous veins specimens were surgically obtained: 35 specimens were from patients with advanced varicose veins and 5 specimens were from pateints with no chronic venous insufficiency. IL-6 concentrations as well as IL-17, TNFα and VEGF concentrations were measured using a sandwich ELISA technique. Substance P was evaluated by a competition ELISA. mRNA VEGF and mRNA TNFα were evaluated by RT-PCR.

Results: IL-17 and substance P were not detected. IL-6 concentrations were comparable among symtomatic and asymptomatic patients. There was a significant statistical difference between TNFα concentrations in the normal veins wall and in varicose veins wall (p≤0.01). However, there was no statistical significant difference when the expression of TNFα mRNA was compared between normal veins and varicose veins and between symptomatic patients and asymptomatic patients. A significant statistical difference was found for the VEGF concentrations and VEGF gene expression between normal veins and varicose veins. Further, VEGF concentrations were statistically different among patients having pain facing their varicosities and patients not reporting pain (p≤0.05). This significant difference was not found when other symptoms were compared.

Conclusion: Further studies are needed before a correlation can be made between inflammatory markers and VEGF and venous symptoms.