gms | German Medical Science

14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)

17.06. - 21.06.2019, Berlin

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Isolated limb perfusion beyond 24h – a potential avenue for global organ sharing, limb resuscitation and optimization

Meeting Abstract

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  • presenting/speaker Nicco Krezdorn - Hannover Medical School, Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Hannover, Germany
  • Fiona MacLeod - MIT, Cambridge, United States
  • Sotirios Tasigiorgos - Brigham and Women's Hospital, Plastic Surgery, Boston, United States
  • Branislav Kollar - Brigham and Women's Hospital, Plastic Surgery, Boston, United States
  • Elazer Edelmann - MIT, Cambridge, United States
  • Bohdan Pomahac - Brigham and Women's Hospital, Plastic Surgery, Boston, United States

International Federation of Societies for Surgery of the Hand. International Federation of Societies for Hand Therapy. 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT). Berlin, 17.-21.06.2019. Düsseldorf: German Medical Science GMS Publishing House; 2020. DocIFSSH19-492

doi: 10.3205/19ifssh1261, urn:nbn:de:0183-19ifssh12615

Veröffentlicht: 6. Februar 2020

© 2020 Krezdorn et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

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Objectives/Interrogation: The maximum allowable ischemia time of 4-6h for amputated limbs is currently the biggest hurdle for broader application of limb allotransplantation and optimized donor-recipient matching. The safe extension of the allowable ischemia time for transport and or restoration and optimization of tissues prior to replantation may be achieved through extracorporeal isolated limb perfusion.

Methods: Based on the results of our experimental studies of ex-vivo perfusion of porcine forelimbs for up to 24h and beyond, and when compared with conventional cold storage on 4°C ice, extracorporeal perfusion with acellular solution at 10°C is a safe means to preserve amputated limbs.

Results and Conclusions: The implications of this progress are many-fold as its success would potentially allow for global organ sharing as well as treatment of injured limbs with compounds unavailable for systemic therapy prior to replantation.