Artikel
Histologic Analysis of the Nail Apparatus in Regard to Subungual Melanoma: Anatomical Study in 21 Cadavers
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Autoren
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Byung Jun Kim
- Seoul National University Hospital, Seoul, South Korea
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Hyunwoo Kim
- Seoul National University Hospital, Seoul, South Korea
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Julong Hu
- Seoul National University Hospital, Seoul, South Korea
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Jin Hyun Kim
- Seoul National University Hospital, Seoul, South Korea
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Hyokyung Yoo
- Seoul National University Hospital, Seoul, South Korea
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Na Hee Yu
- Seoul National University Hospital, Seoul, South Korea
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Sung Tack Kwon
- Seoul National University Hospital, Seoul, South Korea
| Veröffentlicht: | 6. Februar 2020 |
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Gliederung
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Objectives/Interrogation: Breslow thickness is the most important factor that determines treatment plans and the prognosis of the melanoma. However, this cannot be directly applied to the subungual melanoma considering the unique anatomy of the nail unit. The aim of the present study is to analyze the anatomy of the nail unit in order to get information for the functional surgery of the subungual melanoma.
Methods: Twenty-one cadavers were enrolled in this study. Bilateral thumbs and big toes were obtained, and midline longitudinal cross-section slides were made with a thickness of 10 micrometers. The distances from the nail bed to the underlying bone were measured at multiple points including the nail matrix and the hyponychium (Figure 1 [Fig. 1]).
Results and Conclusions: The distance between the nail bed and the underlying bone was the shortest at the nail matrix and the longest at the hyponychium. At the nail matrix, the distance showed 1.10 mm ± 0.43 mm in the thumbs and 1.12 mm ± 0.39 mm in the big toes, respectively. At the hyponychium, the distance was 2.86 mm ± 0.82 mm in the thumbs and 2.71 mm ± 0.80 mm in the big toes, respectively (Table 1 [Tab. 1]).
This is the first study that measured the distance between nail bed and bone at multiple points in Korean. Nail bed showed the shortest distance to the underlying bone at the nail matrix. The results of this study will help to build up a new staging system and surgical methods of subungual melanoma in the future.
