gms | German Medical Science

14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)

17.06. - 21.06.2019, Berlin

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Inflammatory processes and elevated osteoclast activity chaperon atrophic non-union formation in a murine model

Meeting Abstract

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  • Björn Behr - BG Universitätsklinikum Bergmannsheil Bochum, Klinik für Plastische Chirurgie, Handchirurgiezentrum, Bochum, Germany
  • Sonja Schmidt - University Hospital Bergmannsheil Bochum, Bochum, Germany
  • Christoph Wallner - University Hospital Bergmannsheil Bochum, Bochum, Germany
  • Mehran Dadras - University Hospital Bergmannsheil Bochum, Bochum, Germany
  • Mustafa Becerikli - University Hospital Bergmannsheil Bochum, Bochum, Germany
  • Marcus Lehnhardt - BG Universitätsklinikum Bergmannsheil Bochum, Klinik für Plastische Chirurgie, Handchirurgiezentrum, Bochum, Germany
  • presenting/speaker Johannes Maximilian Wagner - University Hospital Bergmannsheil Bochum, Bochum, Germany

International Federation of Societies for Surgery of the Hand. International Federation of Societies for Hand Therapy. 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT). Berlin, 17.-21.06.2019. Düsseldorf: German Medical Science GMS Publishing House; 2020. DocIFSSH19-1903

doi: 10.3205/19ifssh1184, urn:nbn:de:0183-19ifssh11842

Veröffentlicht: 6. Februar 2020

© 2020 Behr et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Objectives/Interrogation: Delayed bone healing, especially in long bones poses one of the biggest problems in orthopeadic and reconstructive surgery and causes tremendous costs every year. There is a need for adequate therapy but first of all we need to explore the causes. Earlier investigations of human scaphoid non-union revealed an elevated osteoclast activity, accompanied by upregulated levels of TGF-beta and RANKL. Interestingly, scaphoid non-union seemed to be well vascularized.

Methods: In the current study, we used a murine femur-defect model to study atrophic non unions.

Different points of times were chosen over an observation period of 10 weeks, to gather insights into the dynamic processes of non-union formation.

Results and Conclusions: Histological and gen-expression analysis indicated enhanced osteoclast activity throughout the observation period, ongoing with elevated levels of TGF-beta, TNF-alpha, MMP9, MMP13 and RANKL. To our surprise, osteoblastogenesis seemed to be unaffected during early stages of non-union formation.

Taken together we gained first insights into the formation process of atrophic non unions, in which inflammatory processes with a highly elevated osteoclast activity seem to play a leading role. Based on this findings new therapeutic options and treatment strategies could be investigated.