gms | German Medical Science

14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)

17.06. - 21.06.2019, Berlin

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Allogenic upper extremity transplantations – opportunities and limitations

Meeting Abstract

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  • presenting/speaker Nicco Krezdorn - Hannover Medical School, Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Hannover, Germany
  • Peter Vogt - Hannover Medical School, Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Hannover, Germany

International Federation of Societies for Surgery of the Hand. International Federation of Societies for Hand Therapy. 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT). Berlin, 17.-21.06.2019. Düsseldorf: German Medical Science GMS Publishing House; 2020. DocIFSSH19-493

doi: 10.3205/19ifssh0510, urn:nbn:de:0183-19ifssh05102

Veröffentlicht: 6. Februar 2020

© 2020 Krezdorn et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

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Objectives/Interrogation: Two decades ago the first successful hand transplantation has kindled the development of previously unthinkable reconstructive and restorative surgical options. Since then more than 100 of these vascularized composite limb allotransplantations (VCA) have been performed. VCA has moved from an experimental approach to a sound surgical option for patients with upper limb amputations.

Methods: Cumulative data from the international cohort suggest adequate functional and aesthetic outcomes. Patient reported quality of life after these interventions is also favourable.

The remaining major limitation towards broader application is the need for continuous life-long immunosuppression. Despite advancements in terms of immunosuppressive protocols, the related infectiology, metabolic, and malignant side effects still remain.

Results and Conclusions: Allogenic limb transplantation is a good option for some amputated patients, although not all. Careful selection and individual risk-benefit evaluation is mandatory prior to considering this novel therapeutic option.