gms | German Medical Science

18th Symposium on Infections in the Immunocompromised Host

International Immunocompromised Host Society

15. to 17.06.2014, Berlin

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Depletion of Dendritic Cells and Lack of Expression of MIP3alpha in Oral Hairy Leukoplakia in HIV Positive Patients

Meeting Abstract

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  • M. Palmieri - Brazil
  • M. Gallottini - Brazil
  • P.H. Braz-Silva - University of São Paulo, São Paulo, Brazil

18th Symposium on Infections in the Immunocompromised Host. Berlin, 15.-17.06.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. Doc14ichs36

doi: 10.3205/14ichs36, urn:nbn:de:0183-14ichs368

Veröffentlicht: 3. Juni 2014

© 2014 Palmieri et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Gliederung

Text

Oral hairy leukoplakia is a benign lesion caused by Epstein-Barr virus (EBV) replication in the epithelium of the lateral borders of the tongue. It is exclusively associated with immunossupression, especially in HIV positive patients. Dendritic cells are related to local imunossurveillance and virus tolerance. MIP3α is a potent chemokine for recruiting immature dendritic cells. We investigated the presence of dentritic cells (CD1a, CD207 and CD83) and expression of MIP3α in 15 oral hairy leukoplakia lesions by immunohistochemistry. All the lesions were diagnosed by EBV in-situ hybridization. In 14 lesions, we found a complete depletion of dendritic cells and lack of MIP3α expression. In only one lesion, did we find a few CD1a positive cells. Patients with oral hairy leukoplakia showed a depletion of dendritic cells and lack of expression of MIP3α in the tongue epithelium.