Artikel
Performance of QuantiFERON TB Gold Test in Detecting Latent Tuberculosis Infection in Brain-Dead Organ Donors in Iran: A Brief Report
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Autoren
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P. Tabarsi
- Shahid Beheshti University of Medical Sciences, Tehran, Iran
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A. Yousefzadeh
- Iran
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K. Najafizadeh
- Iran
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A. Droudinia
- Iran
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R. Bayati
- Iran
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M. Marjani
- Iran
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S. Shafaghi
- Iran
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B. Farokhzad
- Iran
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P. Javanmard
- Iran
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A. Akbar Velayati
- Iran
| Veröffentlicht: | 3. Juni 2014 |
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Gliederung
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Context: With regards to the significant morbidity and mortality of tuberculosis in lung transplant recipients, the identification of brain-dead organ donors with latent tuberculosis by use of the QuantiFERON TB Gold (QFT-G) test may be of help to reduce the risk of TB reactivation and mortality in lung recipients.
Settings and Design: This study was conducted in National Research Institute of Tuberculosis and Lung Diseases (NRITLD) in Iran, from January to March 2013. A total of 38 consecutive brain-dead donors, not currently infected with active tuberculosis, were recruited. Medical records of all study enrollees were reviewed.
Methods and Material: A whole-blood IFN-γ release assay (IGRA) in reaction to ESAT-6, CFP-10 and TB7.7 antigens, was performed and released Interferon-γ was measured via ELISA. The data was analyzed with QFT software.
Statistical analysis used: Demographic, characteristics and other variables were entered in SPSS (version 11.5).
Results: QFT-G test results of 3 donors (7.9%) turned out to be positive, negative for 24 donors (63.1%), and indeterminate in 11 cases (28.9%). 9 donors with indeterminate results (out of 11) showed inadequate reaction to the mitogen in control tubes.
Conclusions: Our study revealed the potential advantages of QFT-G in lowering the incidence of donor-derived post-transplant tuberculosis among lung recipients. However, high rate of indeterminate results restricted the performance of QFT-G in this study.
Key words: Tuberculosis, Transplant, Interferon-γ, Iran
