gms | German Medical Science

18th Symposium on Infections in the Immunocompromised Host

International Immunocompromised Host Society

15. to 17.06.2014, Berlin

Artikel

Artikel empfehlen

Performance of QuantiFERON TB Gold Test Compared With the Tuberculin Skin Test for Detecting Latent Tuberculosis Infection in Lung and Heart Transplant Candidates

Meeting Abstract

Suche in Medline nach

  • M. Mardani - Iran
  • M. Farshidpour - Iran
  • M. Nekoonam - Iran
  • F. Varahram - Iran
  • K. Najafizadeh - Iran
  • N. Mohammadi - Iran
  • B. Sharifkashani - Iran
  • L. Gachkar - Iran
  • B. Farokhzad - Iran
  • A. Droudinia - Iran
  • P. Javanmard - Iran
  • P. Tabarsi - Shahid Beheshti University of Medical Sciences, Tehran, Iran

18th Symposium on Infections in the Immunocompromised Host. Berlin, 15.-17.06.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. Doc14ichs33

doi: 10.3205/14ichs33, urn:nbn:de:0183-14ichs338

Veröffentlicht: 3. Juni 2014

© 2014 Mardani et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Gliederung

Text

Objectives: Evaluation for latent tuberculosis infection is advised before organ transplant. The interferon-gamma release assay has been shown to be more specific than the tuberculin skin test for screening for latent tuberculosis infection. We compared the TST and QuantiFERON-TB Gold In-Tube test for screening for latent tuberculosis infection and agreement between the tests in heart and lung transplant recipients before transplant.

Materials and Methods: Fifty-five adult patients who had been evaluated for heart and lung transplant between September 2011, and September 2012, at Masih Daneshvari Hospital in Iran were prospectively enrolled. We performedTST and QuantiFERON-TB Gold In-Tube test.

Results: Of the 55 patients, 3 (5%) had positive TST results, and 11 (20%) had positive QuantiFERON-TB Gold In-Tube test results. Agreement between the TST and QuantiFERON-TB Gold In-Tube test was fair (Kappa=0.061, 95% CI=- 0.185 - 0.307; P=.56).

Conclusions: The positivity for QuantiFERON-TB Gold In-Tube test was greater than the positivity for TST, and QuantiFERON-TB Gold In-Tube test more accurately determined the risk for latent tuberculosis infection. However, a further longitudinal study is necessary to verify that the QFT-G test would predict developing tuberculosis after heart and lung transplant.

Key words: Transplant, Tuberculin skin test, Interferon-gamma release assay, Tuberculosis