Artikel
Spectrum of Bacteremia in Bone Marrow Transplant Patients from A Tertiary Care Hospital in India
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Veröffentlicht: | 3. Juni 2014 |
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Background: Bacteremias represent severe infectious complications following hematopoietic stem cell transplantation (HSCT). Empirical antibacterial therapy should be be chosen on the basis of local epidemiology. Unlike western data,with predominant Gram positive bacterial infections, we observed predominance of Gram negative bacterial infections in our patients.
Material and Methods: Retrospective analysis of bacteraemia data from patients who have undergone Bone marrow transplant (autologous, allogenic or cord blood) in a tertiary care oncology and transplant centre from South India, between 2011-13.
Results: There were 217 bone marrow transplants in the above mentioned period. Total number of bactermias were 52. Out of these, 46 were gram negative organisms (23 Enterobacteriaeae, 23 Non fermentors) and 4 were gram positive organisms (1 Enterococcus,1 Gemella,1 Steptococcus mitis,1 Staph hominis). Amongst the enterobacteriacaeae, there were 17 Klebsiella and 6 E.Coli). Amongst the non fermentors, 12 were pseudomonas, 7 were ochrobacter anthropi, 1 Elizabethkingiae meningoseptica, 1 ralstonia, 1 aeromonas, 1 SMALT. There was 1 patient with moraxella bacteraemia. Out of 52 bacteraemias only 4 were due to gram positive organisms.
Conclusion: Bacteraemia in our post bone marrow setting were predominantly due to gram negative organisms. This data has important clinical implication, as glycopeptides need not be included in the empirical antibiotic regimen in our setting with very low gram positive infection rates.