gms | German Medical Science

18th Symposium on Infections in the Immunocompromised Host

International Immunocompromised Host Society

15. to 17.06.2014, Berlin

Spectrum of Bacteremia in Bone Marrow Transplant Patients from A Tertiary Care Hospital in India

Meeting Abstract

  • A. Ghafur - South India
  • V.P.R. Devarajan - Apollo Speciality Hospitals, Chennai, South India
  • C.K. Kokila - South India
  • V. Nagvekar - South India

18th Symposium on Infections in the Immunocompromised Host. Berlin, 15.-17.06.2014. Düsseldorf: German Medical Science GMS Publishing House; 2014. Doc14ichs02

doi: 10.3205/14ichs02, urn:nbn:de:0183-14ichs021

Veröffentlicht: 3. Juni 2014

© 2014 Ghafur et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Background: Bacteremias represent severe infectious complications following hematopoietic stem cell transplantation (HSCT). Empirical antibacterial therapy should be be chosen on the basis of local epidemiology. Unlike western data,with predominant Gram positive bacterial infections, we observed predominance of Gram negative bacterial infections in our patients.

Material and Methods: Retrospective analysis of bacteraemia data from patients who have undergone Bone marrow transplant (autologous, allogenic or cord blood) in a tertiary care oncology and transplant centre from South India, between 2011-13.

Results: There were 217 bone marrow transplants in the above mentioned period. Total number of bactermias were 52. Out of these, 46 were gram negative organisms (23 Enterobacteriaeae, 23 Non fermentors) and 4 were gram positive organisms (1 Enterococcus,1 Gemella,1 Steptococcus mitis,1 Staph hominis). Amongst the enterobacteriacaeae, there were 17 Klebsiella and 6 E.Coli). Amongst the non fermentors, 12 were pseudomonas, 7 were ochrobacter anthropi, 1 Elizabethkingiae meningoseptica, 1 ralstonia, 1 aeromonas, 1 SMALT. There was 1 patient with moraxella bacteraemia. Out of 52 bacteraemias only 4 were due to gram positive organisms.

Conclusion: Bacteraemia in our post bone marrow setting were predominantly due to gram negative organisms. This data has important clinical implication, as glycopeptides need not be included in the empirical antibiotic regimen in our setting with very low gram positive infection rates.