Artikel
Blood pressure values correlate with the metabolic burden in obese patients
Die Blutdruckwerte korrelieren bei adipösen Patienten mit der metabolischen Belastung
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Autoren
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J. Scholze
- Charité CCM, Inst. f. Pharmakologie u. Toxikologie (Berlin, D)
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T. Unger
- Charité CCM, Inst. f. Pharmakologie u. Toxikologie (Berlin, D)
| Veröffentlicht: | 11. November 2004 |
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Gliederung
Text
Obesity, defined as exceeding a body mass index of 30 kg/m² has reached endemic proportions and is a substantial risk factor for metabolic and cardiovascular diseases. Up to now it remains unclear, why many obese patients develop metabolic disorders while others do not.
To investigate the influence of blood pressure levels on metabolic parameters, we compared these data from 6360 obese patients of the sibutramine-PMS-study with a BMI of at least 27 kg/m² [Ref. 1].
Patients were divided into 3 groups according blood pressure levels (A:<140/90 mmHg- normotensive, B: 140-159/90-99 mmHg-stage 1 hypertensive and C: > 160/100 mmHg-stage 2 hypertensive). The following parameters were determined: Chol, LDL, HDL, triglyceride (TG), Glucose, HbA1c, uric acid, heart rate (HR). Groups were not different with respect to body weight, gender and age.
All differences of the parameters between the groups listed in table 1 [Tab. 1], were significant p < 0,05.
In addition, there was a significant increase of HR (74,7 vs 77,0 vs. 82,1 b/min) from group A to C.
We found a strong dependence of metabolic disorders on blood pressure levels. Both seems to be influenced by the degree of activation of the sympathetic nervous system.
