gms | German Medical Science

The problem of chronic polypoid rhinosinusitis (CPRS) today remains one of the most important in otolaryngology, so CPRS has great medical and social significance, as evidenced by the high incidence, a tendency to increase, a high level of loading for the disease and the need for medical, rehabilitation, social and other activities for quite a considerable period of life of patients.

Purpose: to study the performance of IgE in serum of patients with chronic “eosinophilic” polypous rhinosinusitis.

Material and methods: 150 patients were examined with CPRS who were treated at the ENT department of the 3^rd clinic of Tashkent Medical Academy from 2009 to 2013. Diagnosis CPRS exhibited by history, objective status, the state of ENT, endoscopy, X-ray and computerized tomography. 142 patients underwent surgery appropriate dissemination polypoid process, 8 patients refused surgery and received conservative treatment. Morphologic study of nasal polyps of 86 patients revealed eosinophilic infiltration of the stroma of the mucosa, 56 patients – neutrophilic infiltration of the stroma of the mucosa. Immunological study was conducted at the Institute of Immunology and Allergology Uzbek Academy of Sciences.

Results and discussion: Immunological study of patients with “eosinophilic” polypoid rhinosinusitis showed that patients with “eosinophilic” polyps level of IgE in serum was elevated and consists 386,7±277,4 IU/ml. Patients with “neutrophils” polyps level of IgE was within the normal range – 18,9±11,4 IU/ml.

Conclusions: From the above it follows that the serum IgE levels rise to high levels in eosinophilic infiltration, but it remains within the normal neutrophil infiltration in the stroma of the nasal mucosa in chronic polypoid rhinosinusitis.

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