gms | German Medical Science

83. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

16.05. - 20.05.2012, Mainz

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Loss Using Three-Dimensional Polyacrylamide Gel-Based Microarray Method

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  • corresponding author Guihua Xia - Beilun Branch of the First People's Hospital of Beilun, Medical College of Zheji, Ningbo, P.R. China
  • Weiwei Gao - Beilun Branch of the First People's Hospital of Beilun, Medical College of Zheji, Ningbo, P.R. China
  • Ke Ji - Beilun Branch of the First People's Hospital of Beilun, Medical College of Zheji, Ningbo, P.R. China
  • Shaosheng Liu - Beilun Branch of the First People's Hospital of Beilun, Medical College of Zheji, Ningbo, P.R. China
  • Bo Wan - Beilun Branch of the First People's Hospital of Beilun, Medical College of Zheji, Ningbo, P.R. China
  • Junfeng Luo - Wuxi Agene Bioinformatics & Biotechnology Co., Ltd, Wuxi, P.R. China
  • Yunfei Bai - State Key Laboratory of Bioelectronics, Southeast University, Nanjing, P.R. China

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 83. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Mainz, 16.-20.05.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. Doc12hnod572

doi: 10.3205/12hnod572, urn:nbn:de:0183-12hnod5729

Veröffentlicht: 4. April 2012

© 2012 Xia et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Gliederung

Text

Noise induced hearing loss (NIHL) is a complex occupational hazard caused by an interaction between genetic and environmental factors. Millions of Chinese industrial people are daily exposed to high level of noise. Although the environmental risk factors have been studied extensively, the nature of the genetic factors contributing to HIHL has not yet been clarified. In this study, we investigated 15 single nucleotide polymorphisms (SNPs) in 6 candidate genes influence susceptibility to noise in Chinese noise-exposed workers. Data from 3-dimensional polyacrylamide gel-based microarray platforms were analyzed. 103 blood samples were collected from noise-exposed laborers in Ningbo, Zhejiang, China. Subsequently, the interaction between noise exposure and genotypes and their effect on NIHL were analysed using logistic regression. Two interesting results were observed between noise exposure levels and genotypes of three SNPs, hence confirming that they are NIHL susceptibility genes in Chinese population.