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83. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

16.05. - 20.05.2012, Mainz

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An animal model of labyrinthine concussion in wistar rat

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  • corresponding author Hong Lu - the 2nd. Hospital of Hebei Medical University, Shijiazhuang, P.R.China
  • Ou Xu - The 2nd. Hospital of Hebei Medical University, Shijiazhuang, P.R. China
  • Zhe Lv - The 2nd. Hospital of Hebei Medical University, Shijiazhuang, P.R. China
  • Qiang He - The 2nd. Hospital of Hebei Medical University, Shijiazhuang, P.R. China

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 83. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Mainz, 16.-20.05.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. Doc12hnod473

doi: 10.3205/12hnod473, urn:nbn:de:0183-12hnod4739

Veröffentlicht: 4. April 2012

© 2012 Lu et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Gliederung

Text

Objective: To study if the Wistar rat model of cerebral concussion may be developed as the model of labyrinthine concussion.

Methods: Forty healthy male Wistar rats were divided into group A（the control group）, B(30 minutes after impact) , C(1 hour after impact) and D(1 day after impact). The DPOAE audiogram (ｆ2/ｆ1=1.2, Ｌ1=65dBSPL, Ｌ2=55dBSPL) at 0.5,0.7,1,1.4,2,3,4,6 and 8kHz were analyzed in the three circumstances. The values of ABR were simultaneously measured. The changes of cochlear hair cells were observed under the scanning electron microscope.

Results: The increased values of ABR were observed in group B,C and D (P<0.05). The DPOAE significant decreased at 2 kHz after rats were rammed in group C and group D (P<0.05). cochlea outer hair cells on the intermediate and basefond circumvolutio were showed disordered in group B and lightly lodging in the group D by scanning electron microscope.

Conclusion: The animal model of cerebral concussion can be used as the model of labyrinthine concussion in Wistar rats.