Artikel
Gene-expression study of possible target genes harbouring the chromosomal region 3q26-28 in HNSCC
Suche in Medline nach
Autoren
Veröffentlicht: | 24. April 2007 |
---|
Gliederung
Text
Amplification of chromosomal region 3q26-28 is a common event in head and neck squamous cell carcinoma. We applied a real time PCR to evaluate gene expression of several candidate oncogenes harbouring 3q26-28 in tumor samples as well as in histologically normal tissue samples nearby the tumor margin. It has been detected an overexpression of particular genes (PIK3CA, SSCRO and others) in tumor surrounding samples which might play a crucial role in early stages of cancerogenesis and tumor progression.
Supported by: Tumorstiftung Kopf-Hals (Germany), Grant GAUK Nr.203435 36/06 (Czech Republic)