Artikel
Inflammation and metastasis in laryngeal squamous cell carcinoma (LSCC)
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Autoren
Veröffentlicht: | 7. September 2016 |
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Gliederung
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Introduction: In the tumor microenvironment of head and neck cancer an interaction between tumor cells and tumor infiltrating stromal host cells takes place. Tumor biology and -characteristics are severely influenced by these inflammatory processes. Aim of this study was to analyze the inflammatory tumor microenvironment and its impact on metastasis in patients with LSCC.
Material and methods: 112 patients with histologically proven laryngeal squamous cell carcinoma have been included. Immunohistochemical expression of CD45, COX-2 and MMP-9 was analyzed semiquantitatively for stroma and tumor and its association with patients’ N-status was assessed.
Results: We found a significantly higher number of metastasized patients in the group of CD-45 highly stained patients compared to the group with low CD-45 expression in the stroma (p = 0.001). A high amount of CD45-positive cells in the stroma was positively correlated with the expression of stromal MMP-9 (p = 0.024). Tumoral COX-2 expression was significantly higher in the group of metastasized patients compared to patients with an N0 status (p = 0.001).
Discussion: A strong leucocytic infiltrate was associated with higher stromal MMP-9 expression and higher metastasis in LSCC. Our results suggest that both tumor cell (COX-2) and tumor stroma (leucocytes) characteristics might influence metastasis of laryngeal squamous cell carcinoma.