gms | German Medical Science

87. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

04.05. - 07.05.2016, Düsseldorf

Inflammation and metastasis in laryngeal squamous cell carcinoma (LSCC)

Meeting Abstract

  • corresponding author presenting/speaker Benedikt Höing - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Essen, Germany, Essen, Germany
  • author Oliver Kanaan - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Essen, Germany, Essen, Germany
  • author Benjamin Kansy - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Essen, Germany, Essen, Germany
  • author Anke Schlüter - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Essen, Germany, Essen, Germany
  • author Robert Petri - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Essen, Germany, Essen, Germany
  • author Agnes Bankflavi - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Essen, Germany, Essen, Germany
  • author Stephan Lang - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Essen, Germany, Essen, Germany
  • author Sven Brandau - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Essen, Germany, Essen, Germany

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. 87th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. Düsseldorf, 04.-07.05.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. Doc16hno14

doi: 10.3205/16hno14, urn:nbn:de:0183-16hno143

Veröffentlicht: 7. September 2016

© 2016 Höing et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Introduction: In the tumor microenvironment of head and neck cancer an interaction between tumor cells and tumor infiltrating stromal host cells takes place. Tumor biology and -characteristics are severely influenced by these inflammatory processes. Aim of this study was to analyze the inflammatory tumor microenvironment and its impact on metastasis in patients with LSCC.

Material and methods: 112 patients with histologically proven laryngeal squamous cell carcinoma have been included. Immunohistochemical expression of CD45, COX-2 and MMP-9 was analyzed semiquantitatively for stroma and tumor and its association with patients’ N-status was assessed.

Results: We found a significantly higher number of metastasized patients in the group of CD-45 highly stained patients compared to the group with low CD-45 expression in the stroma (p = 0.001). A high amount of CD45-positive cells in the stroma was positively correlated with the expression of stromal MMP-9 (p = 0.024). Tumoral COX-2 expression was significantly higher in the group of metastasized patients compared to patients with an N0 status (p = 0.001).

Discussion: A strong leucocytic infiltrate was associated with higher stromal MMP-9 expression and higher metastasis in LSCC. Our results suggest that both tumor cell (COX-2) and tumor stroma (leucocytes) characteristics might influence metastasis of laryngeal squamous cell carcinoma.