Artikel
FDG Tracer-Uptake In Locally Advanced Oropharyngeal Squamous Cell Carcinoma
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Veröffentlicht: | 23. Juli 2012 |
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Introduction: HPV-associated oropharyngeal squamous cell carcinoma (OSCC) is an own tumor entity with increasing incidence and different metastatic behavior compared to the non-HPV-associated OSCC. PET/CT has been described as a predictive marker for outcome of irradiation therapy in non-HPV-associated OSCC but its prognostic value for the HPV-associated OSCC is currently unknown.
Methods: 18-F FDG-PET/CT was conducted in 20 patients with locally advanced OSCC before panendoscopy. HPV-status was obtained via PCR and p16-immunohistochemistry. SUV-values of the primary tumor and corresponding metastases in both tumor entities were analysed.
Results: 6 out of 20 patients (30%) showed HPV-associated OSCC. Distribution of SUV-values of the primary tumors neither differed in early stage (10.0 ± 3.7 – HPVneg. vs. 8.2 ± 4.3 – HPVpos.; p=0.265) nor in late stage of the examination (11.5 ± 4.7 – HPVneg. vs. 10.0 ± 5.0 – HPVpos.; p=0.303). Likewise, there was no significant difference in SUV-values of cervical nodes in early stage (5.9 ± 2.3 – HPVneg. vs. 8.1 ± 4.8 – HPVpos.; p=0.516) or in late stage (7.6 ± 3.3 – HPVneg. vs. 9.9 ± 6.4 – HPVpos.; p=0.897).
Conclusion: Currently, there is no indication that FDG tracer-uptake differs between HPV-positive and HPV-negative OSCC. However, experimental research has shown that the HPV-E7 oncoprotein induces a high glucose metabolism within tumor cells. Therefore, the study results have to be proven with higher case numbers.